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CAS No 80474-14-2 , Fluticasone propionate

  • Name: Fluticasone propionate
  • Synonyms: (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester;S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate;Fluticasone propionate; (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester;
  • CAS Registry Number:
  • Density: 1.32 g/cm3
  • Refractive index: 31 ° (C=1, Dioxane)
  • Safety Statements: 22-24/25
  • Molecular Weight: 500.57
  • InChI: InChI=1/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16?,18+,19+,22+,23+,24+,25+/m1/s1
  • Risk Statements: S22;S24/25
  • Molecular Formula: C25H31F3O5S
  • Molecular Structure:CAS No:80474-14-2 Fluticasone propionate

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References of Fluticasone propionate
Title: Fluticasone Propionate
CAS Registry Number: 80474-14-2
CAS Name: (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester
Synonyms: S-fluoromethyl 6a,9a-difluoro-11b-hydroxy-16a-methyl-17a-propionyloxy-3-oxoandrosta-1,4-diene-17b-carbothioate
Manufacturers' Codes: CCI-18781
Trademarks: Cutivate (GSK); Flixonase (GSK); Flixotide (GSK); Flonase (GSK); Flovent (GSK); Flunase (GSK)
Molecular Formula: C25H31F3O5S
Molecular Weight: 500.57
Percent Composition: C 59.99%, H 6.24%, F 11.39%, O 15.98%, S 6.41%
Literature References: Derivative of flumethasone, q.v. Prepn: NL 81 00707; G. H. Phillipps et al., US 4335121 (1981, 1982 both to Glaxo). Series of articles on structure-activity, pharmacology and clinical studies: Respir. Med. 84, Suppl. A, 19-35 (1990). Clinical trials in allergic rhinitis: E. O. Meltzer et al., J. Allergy Clin. Immunol. 86, 221 (1990). Evaluation in untreated celiac disease: H. C. Mitchison et al., Gut 32, 260 (1991). Clinical trials in COPD: P. L. Paggiaro et al., Lancet 351, 773 (1998); P. S. Burge et al., Br. Med. J. 320, 1297 (2000). Clinical comparison with zafirlukast, q.v., in persistant asthma: J. H. Brabson et al., Am. J. Med. 113, 15 (2002).
Properties: Crystals, mp 272-273° (dec). [a]D +30° (c = 0.35). Practically insol in water. Freely sol in DMSO, DMF; slightly sol in methanol, 95% ethanol.
Melting point: mp 272-273° (dec)
Optical Rotation: [a]D +30° (c = 0.35)
Therap-Cat: Antiallergic; antiasthmatic; anti-inflammatory.
Keywords: Antiallergic (Steroidal, Nasal); Glucocorticoid; Antiasthmatic (Steroidal, Inhalant).