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CAS No 80474-14-2 , Fluticasone propionate

  • Name: Fluticasone propionate
  • Synonyms: (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester;S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate;Fluticasone propionate; (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester;
  • CAS Registry Number:
  • Density: 1.32 g/cm3
  • Refractive index: 31 ° (C=1, Dioxane)
  • Safety Statements: 22-24/25
  • Molecular Weight: 500.57
  • InChI: InChI=1/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16?,18+,19+,22+,23+,24+,25+/m1/s1
  • Risk Statements: S22;S24/25
  • Molecular Formula: C25H31F3O5S
  • Molecular Structure:CAS No:80474-14-2 Fluticasone propionate
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80474-14-2 Fluticasone Propionate

  • China Nanjing Samwon International Limited [Importer/Exporter]
  • Tel: +86-(25)-84873444
  • Fax: +86-(25)-84507436
  • Address: 1108, BLDG B, New Century Plaza, No 1, South Taiping Rd., Nanjing, Jiangsu 210002, Nanjing,JiangsuChina
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80474-14-2 Fluticasone Propionate

  • Fluticasone Propionate
  • India J.INC. [Manufacturer]
  • Tel: +91 79 30071152, 30071190, 30071175, 30071153
  • Fax: +91 79 30071176, 26574630
  • Address: # 95, Rangwala Towers, Law garden, Ellisbridge, Ahmedabad 380006, Gujarat State, India. 380006 AhmedabadINDIA Ahmedabad,nullIndia
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80474-14-2 Fluticasone propionate

  • China suchem pharma co.,limited [Manufacturers]
  • Tel: 86-57781172668
  • Fax: 8657785505511
  • Address: wenzhou, China Wenzhou,ZhejiangChina
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80474-14-2 Fluticasone Propionate

  • Fluticasone Propionate, 99%min
  • China Shanghai Everchem Co.,Ltd. [Manufacturer]
  • Tel: +86-21-5192-3949
  • Fax: +86-21-5192-3940
  • Address: No.277 Zheqiao Road,
    Shanghai 201206 China null,nullChina
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80474-14-2 Fluticasone Propionate

  • China Luna Chemicals Co.,Ltd. null
  • Fax: +86-571-85775960
  • Address: 1502-1503,No.310 North Zhong Shan Rd., Hangzhou,China null,nullChina
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80474-14-2 Fluticasone propionate

  • China Kingland Chemicals Company Limited [Manufacturers]
  • Tel: +86-571-87211518,87229835
  • Fax: +86-571-87211508
  • Address: Room No. 1806-1808, Jinfeng Mansion, No.281 Zhong He Zhong Road, Hangzhou, China. null,zhejiangChina
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80474-14-2 FLUTICASONE PROPIONATE

  • China Ancheng Pharma Limited [Manufacturers]
  • Tel: +86-755-82713308
  • Fax: 0086-755-82713413
  • Address: Flat 1812, 18/F., Min Hua Building, 7 Jing Tian Bei Steet, Futian District,Shenzhen,China Shenzhen,guangdongChina
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80474-14-2 Fluticasone propionate

  • China ZHEJIANG HOLYPHARM BIOTECH CO.,LTD [Manufacturers]
  • Tel: 86-533-8585678
  • Fax: 86-57187357695
  • Address: Room C 13th Floor, West Wing International Garden, No.160 Tianmushan Road, Xihu District, Hangzhou City, China null,nullChina
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80474-14-2 Fluticasone propionate

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80474-14-2 Fluticasone Propionate

  • Fluticasone Propionate
  • China Hallopharma [Manufacturer]
  • Tel: 0086-23-67030808
  • Fax: 0086-23-67030818
  • Address: 17F,Venus Science Incubate Center,No.60 Xingguang Road,New North Zone,401121 ChongqingCHINA Chongqing,nullChina
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References of Fluticasone propionate
Title: Fluticasone Propionate
CAS Registry Number: 80474-14-2
CAS Name: (6a,11b,16a,17a)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid S-(fluoromethyl) ester
Synonyms: S-fluoromethyl 6a,9a-difluoro-11b-hydroxy-16a-methyl-17a-propionyloxy-3-oxoandrosta-1,4-diene-17b-carbothioate
Manufacturers' Codes: CCI-18781
Trademarks: Cutivate (GSK); Flixonase (GSK); Flixotide (GSK); Flonase (GSK); Flovent (GSK); Flunase (GSK)
Molecular Formula: C25H31F3O5S
Molecular Weight: 500.57
Percent Composition: C 59.99%, H 6.24%, F 11.39%, O 15.98%, S 6.41%
Literature References: Derivative of flumethasone, q.v. Prepn: NL 81 00707; G. H. Phillipps et al., US 4335121 (1981, 1982 both to Glaxo). Series of articles on structure-activity, pharmacology and clinical studies: Respir. Med. 84, Suppl. A, 19-35 (1990). Clinical trials in allergic rhinitis: E. O. Meltzer et al., J. Allergy Clin. Immunol. 86, 221 (1990). Evaluation in untreated celiac disease: H. C. Mitchison et al., Gut 32, 260 (1991). Clinical trials in COPD: P. L. Paggiaro et al., Lancet 351, 773 (1998); P. S. Burge et al., Br. Med. J. 320, 1297 (2000). Clinical comparison with zafirlukast, q.v., in persistant asthma: J. H. Brabson et al., Am. J. Med. 113, 15 (2002).
Properties: Crystals, mp 272-273° (dec). [a]D +30° (c = 0.35). Practically insol in water. Freely sol in DMSO, DMF; slightly sol in methanol, 95% ethanol.
Melting point: mp 272-273° (dec)
Optical Rotation: [a]D +30° (c = 0.35)
Therap-Cat: Antiallergic; antiasthmatic; anti-inflammatory.
Keywords: Antiallergic (Steroidal, Nasal); Glucocorticoid; Antiasthmatic (Steroidal, Inhalant).