Home > Name List By other > (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-y... China

CAS No 81-27-6 , (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-
hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic
acid Search by region : China

  • Name: (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
    5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-
    hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
    5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic
    acid
  • Synonyms: Senna (powdered); 81-27-6; C42H38O20; sennoside;(9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
    5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-
    hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
    5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic
    acid; EINECS 201-339-9;Sennoside A; Sennoside A; G; NSC 112929; NSC112929;
  • CAS Registry Number:
  • Melting Point: 200oC-240oC
  • Density: 1.743g/cm3
  • Refractive index: 1.762
  • Safety Statements: 22-45
  • EINECS: 201-339-9
  • Molecular Weight: 862.73912
  • InchiKey: IPQVTOJGNYVQEO-KGFNBKMBSA-N
  • InChI: InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-
    25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38
    (54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20
    (28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,
    58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1
  • Risk Statements: 22
  • Molecular Formula: C42H38O20
  • Molecular Structure:CAS No:81-27-6 (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,<br />5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-<br />hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,<br />5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic<br />acid

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81-27-6 Sennoside A

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81-27-6 potassium

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81-27-6 Sennoside A

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References of (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-
hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic
acid
Title: Sennosides
Trademarks: Colonorm (Mundipharma); Glysennid (Dorsey); Nytilax (Rohto); Pursennid (Novartis)
Molecular Formula: C42H38O20
Molecular Weight: 862.74
Percent Composition: C 58.47%, H 4.44%, O 37.09%
Literature References: Anthraquinone glucosides found in senna in equal amts and in the rhubarbs where sennoside A predominates. Isoln from Tinnevelly senna (Cassia angustifolia Vahl, Leguminosae): Stoll et al., Helv. Chim. Acta 32, 1892 (1949); GB 804232 (1958 to Byk-Gulden); Khorana, Sanghavi, J. Pharm. Sci. 53, 110 (1964); Menssen et al., US 3517269 (1970 to Nattermann & Cie). Isoln from the rhyzome of Rheum palmatum L.: Zwaving, Planta Med. 13, 474 (1965). Isoln of sennoside A from rhubarb: Miyamoto et al., Yakugaku Zasshi 87, 1040 (1967). Sennosides B, C, D, E, and F have also been isolated from rhubarb, see Oshio et al., Chem. Pharm. Bull. 22, 823 (1974). Structure: Stoll et al., Helv. Chim. Acta 33, 313 (1950). Sennoside A is built up from the dextrorotatory aglucon sennidin A and D-glucose. Sennoside B is built up from the intramolecularly compensated meso-sennidin B and D-glucose. Review: Stoll, Becker, Fortschr. Chem. Org. Naturst. 7, 248 (1950). Transport and mechanism of action studies: Dobbs et al., Farmaco Ed. Sci. 30, 147 (1975).
 
Derivative Type: Sennoside A
CAS Registry Number: 81-27-6
CAS Name: (R*,R*)-5,5¢-Bis(b-D-glucopyranosyloxy)-9,9¢,10,10¢-tetrahydro-4,4¢-dihydroxy-10,10¢-dioxo[9,9¢-bianthracene]-2,2¢-dicarboxylic acid
Properties: Rectangular yellow plates from dil acetone, dec 200-240°. [a]D20 -164° (c = 0.1 in 60% acetone); [a]D20 -147° (c = 0.1 in 70% acetone); [a]D20 -24° (c = 0.2 in 70% dioxane). Insol in water, benzene, ether, chloroform. Sparingly sol in methanol, Carbitol, acetone, dioxane. The soly increases tremendously in water-miscible organic solvents contg an optimum of 30% w/w of water. Sol in aq solns of sodium bicarbonate. Sennoside A can be slowly isomerized to B in NaHCO3 soln at 80°.
Optical Rotation: [a]D20 -164° (c = 0.1 in 60% acetone); [a]D20 -147° (c = 0.1 in 70% acetone); [a]D20 -24° (c = 0.2 in 70% dioxane)
 
Derivative Type: Sennoside B
CAS Registry Number: 128-57-4
CAS Name: (9R,9¢S)-5,5¢-Bis(b-D-glucopyranosyloxy)-9,9¢,10,10¢-tetrahydro-4,4¢-dihydroxy-10,10¢-dioxo[9,9¢-bianthracene]-2,2¢-dicarboxylic acid
Properties: Light yellow prisms from dil acetone; fine needles from water, dec 180-186°. [a]D20 -100° (c = 0.2 in 70% acetone); [a]D20 -67° (c = 0.4 in 70% dioxane). uv max (0.5% NaHCO3): 270, 308, 355 nm. Has the same soly characteristics as sennoside A, but is more sol. Can be recrystallized from large amounts of hot water. Keep protected from air and light.
Optical Rotation: [a]D20 -100° (c = 0.2 in 70% acetone); [a]D20 -67° (c = 0.4 in 70% dioxane)
Absorption maximum: uv max (0.5% NaHCO3): 270, 308, 355 nm
 
Therap-Cat: Cathartic.
Keywords: Laxative/Cathartic.