Home > Name List By other > (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-y...

CAS No 81-27-6 , (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-
hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic
acid

  • Name: (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
    5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-
    hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
    5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic
    acid
  • Synonyms: Senna (powdered); 81-27-6; C42H38O20; sennoside;(9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
    5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-
    hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
    5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic
    acid; EINECS 201-339-9;Sennoside A; Sennoside A; G; NSC 112929; NSC112929;
  • CAS Registry Number:
  • Melting Point: 200oC-240oC
  • Density: 1.743g/cm3
  • Refractive index: 1.762
  • Safety Statements: 22-45
  • EINECS: 201-339-9
  • Molecular Weight: 862.73912
  • InchiKey: IPQVTOJGNYVQEO-KGFNBKMBSA-N
  • InChI: InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-
    25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38
    (54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20
    (28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,
    58)/t23-,24-,25-,26-,31-,32-,35+,36+,37-,38-,41-,42-/m1/s1
  • Risk Statements: 22
  • Molecular Formula: C42H38O20
  • Molecular Structure:CAS No:81-27-6 (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,<br />5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-<br />hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,<br />5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic<br />acid
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81-27-6 SENNOSIDE A

  • Germany ABCR GmbH & Co KG [Manufacturer]
  • Tel: +49 721 95061-0
  • Fax: +49 721 95061-80
  • Address: Im Schlehert 10
    76187 Karlsruhe
    Germany ,Germany
Contact Supplier

81-27-6 Sennoside A

  • Sennoside A Synonym: GLYSENNIDE;SENNOSIDE;SENNOSIDE A;PURSENNID;PURSENNIDE;Tomato juice;Sennoside A std.;SENNOSIDEA60% CAS: 81-27-6 EINECS: 201-339-9 Assay: 8% M.F: C42h38020 M.W: 962.74 M.S: Specific Rotate: MP or BP: Density: Appearance: Applicatio...
  • Min. Order: 500
  • China Hubei Saichuang Group [Manufacturer, Trading Company]
  • Tel: 86-027-50756064
  • Address: Zhongshan Road wuhan,HubeiChina
Contact Supplier

81-27-6 potassium

  • 1) Specification Appearance: black brown powder Size: 60-80 mesh Water-solubility: 95%-97% Humic acid (dry base): 55%-60% Potassium content (K2O): 6%-8% PH:9-11 2) Package: 25kg /PP.woven bag or 25kg/ paper bag with inner plastic lining
  • China Shenyang Humate Technology Co., Ltd. [Manufacturer, Trading Company]
  • Tel: 86-24-86237323
  • Address: No.9, Beiling Street, Huanggu District, Shenyang 110032, P.R.China shenyang,LiaoningChina
Contact Supplier

81-27-6 SENNOSIDE A 60%

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
Contact Supplier

81-27-6 Sennoside A

  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
  • Tel: +86-(21)-58116473
  • Fax: +86-(21)-61094103
  • Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318, shanghai,shanghaiChina
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81-27-6 Sennoside A

  • English name:Sennoside A CAS:A81-27-6 Purity:HPLC>98% Detail Information: Molecular Formula : C32H46O16 Molecular Weight : 686.71g/mol Original:Cassia angustifolia Vahl Synonyms: (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4, Packag...
  • China Baoji Herbest Bio-Tech Co.,Ltd [Manufacturer]
  • Tel: 86-917-8883868
  • Address: GaoXin 6th RD, Baoji City ,ShannxiProvience China baoji,ShanxiChina
Contact Supplier

81-27-6 A3065 SENNOSIDE A

  • United Kingdom Carbosynth Limited [Manufacturer]
  • Tel: +44 (0)1635 578444
  • Fax: +44 (0)1635 579444
  • Address: Carbosynth Limited
    8&9 Old Station Business Park
    Compton
    Berkshire
    RG20 6NE
    UK ,United Kingdom
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81-27-6 SENNOSIDE A

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
Contact Supplier

81-27-6 Sennoside A 60%

  • Germany AppliChem mbH []
  • Tel: +49 6151 93 57 0
  • Fax: +49 6151 93 57 11
  • Address: Ottoweg 4 D-64291 Darmstadt ,Germany
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81-27-6 SENNOSID A HPLC GRADE

  • Germany AppliChem GmbH [Manufacturer]
  • Tel: +49 6151 93 57 0
  • Fax: +49 6151 93 57 11
  • Address: AppliChem GmbH
    Ottoweg 4
    64291 Darmstadt
    Germany ,Germany
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References of (9R)-9-[(9R)-2-carboxy-4-hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracen-9-yl]-4-
hydroxy-10-oxo-5-[(2S,3R,4S,5S,6R)-3,4,
5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-9H-anthracene-2-carboxylic
acid
Title: Sennosides
Trademarks: Colonorm (Mundipharma); Glysennid (Dorsey); Nytilax (Rohto); Pursennid (Novartis)
Molecular Formula: C42H38O20
Molecular Weight: 862.74
Percent Composition: C 58.47%, H 4.44%, O 37.09%
Literature References: Anthraquinone glucosides found in senna in equal amts and in the rhubarbs where sennoside A predominates. Isoln from Tinnevelly senna (Cassia angustifolia Vahl, Leguminosae): Stoll et al., Helv. Chim. Acta 32, 1892 (1949); GB 804232 (1958 to Byk-Gulden); Khorana, Sanghavi, J. Pharm. Sci. 53, 110 (1964); Menssen et al., US 3517269 (1970 to Nattermann & Cie). Isoln from the rhyzome of Rheum palmatum L.: Zwaving, Planta Med. 13, 474 (1965). Isoln of sennoside A from rhubarb: Miyamoto et al., Yakugaku Zasshi 87, 1040 (1967). Sennosides B, C, D, E, and F have also been isolated from rhubarb, see Oshio et al., Chem. Pharm. Bull. 22, 823 (1974). Structure: Stoll et al., Helv. Chim. Acta 33, 313 (1950). Sennoside A is built up from the dextrorotatory aglucon sennidin A and D-glucose. Sennoside B is built up from the intramolecularly compensated meso-sennidin B and D-glucose. Review: Stoll, Becker, Fortschr. Chem. Org. Naturst. 7, 248 (1950). Transport and mechanism of action studies: Dobbs et al., Farmaco Ed. Sci. 30, 147 (1975).
 
Derivative Type: Sennoside A
CAS Registry Number: 81-27-6
CAS Name: (R*,R*)-5,5¢-Bis(b-D-glucopyranosyloxy)-9,9¢,10,10¢-tetrahydro-4,4¢-dihydroxy-10,10¢-dioxo[9,9¢-bianthracene]-2,2¢-dicarboxylic acid
Properties: Rectangular yellow plates from dil acetone, dec 200-240°. [a]D20 -164° (c = 0.1 in 60% acetone); [a]D20 -147° (c = 0.1 in 70% acetone); [a]D20 -24° (c = 0.2 in 70% dioxane). Insol in water, benzene, ether, chloroform. Sparingly sol in methanol, Carbitol, acetone, dioxane. The soly increases tremendously in water-miscible organic solvents contg an optimum of 30% w/w of water. Sol in aq solns of sodium bicarbonate. Sennoside A can be slowly isomerized to B in NaHCO3 soln at 80°.
Optical Rotation: [a]D20 -164° (c = 0.1 in 60% acetone); [a]D20 -147° (c = 0.1 in 70% acetone); [a]D20 -24° (c = 0.2 in 70% dioxane)
 
Derivative Type: Sennoside B
CAS Registry Number: 128-57-4
CAS Name: (9R,9¢S)-5,5¢-Bis(b-D-glucopyranosyloxy)-9,9¢,10,10¢-tetrahydro-4,4¢-dihydroxy-10,10¢-dioxo[9,9¢-bianthracene]-2,2¢-dicarboxylic acid
Properties: Light yellow prisms from dil acetone; fine needles from water, dec 180-186°. [a]D20 -100° (c = 0.2 in 70% acetone); [a]D20 -67° (c = 0.4 in 70% dioxane). uv max (0.5% NaHCO3): 270, 308, 355 nm. Has the same soly characteristics as sennoside A, but is more sol. Can be recrystallized from large amounts of hot water. Keep protected from air and light.
Optical Rotation: [a]D20 -100° (c = 0.2 in 70% acetone); [a]D20 -67° (c = 0.4 in 70% dioxane)
Absorption maximum: uv max (0.5% NaHCO3): 270, 308, 355 nm
 
Therap-Cat: Cathartic.
Keywords: Laxative/Cathartic.