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CAS No 82410-32-0 , 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one

  • Name: 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
  • Synonyms: 82410-32-0; Gancyclovir; GANCICLOVIR SODIUM; Vitrasert; Hydroxyacyclovir;Cytovene; Ganciclovirum;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one; Cymevene; Zirgan;
  • CAS Registry Number:
  • Melting Point: 250 ºC
  • Flash Point: 675 ºC at 760 mmHg
  • Boiling Point: 675 ºC at 760 mmHg
  • Density: 1.81 g/cm3
  • Water Solubility: 0.1 M HCl: 10 mg/mL
  • Safety Statements: R46;R60;R61
  • Hazard Symbols: T: Toxic;
  • Flash Point: 675 ºC at 760 mmHg
  • Molecular Weight: 255.23062
  • InchiKey: IRSCQMHQWWYFCW-UHFFFAOYSA-N
  • InChI: InChI=1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,
    5,15-16H,1-2,4H2,(H3,10,12,13,17)
  • Risk Statements: S53;S36/37/39;S45
  • Molecular Formula: C9H13N5O4
  • Molecular Structure:CAS No:82410-32-0 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one

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References of 2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one
Title: Ganciclovir
CAS Registry Number: 82410-32-0
CAS Name: 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one
Synonyms: 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine; 2￠-nor-2￠-deoxyguanosine; DHPG; 2￠NDG
Manufacturers' Codes: BIOLF-62; BW-B759U; BW-759; BW-759U; RS-21592
Molecular Formula: C9H13N5O4
Molecular Weight: 255.23
Percent Composition: C 42.35%, H 5.13%, N 27.44%, O 25.07%
Literature References: Nucleoside analog structurally related to acyclovir, q.v. Prepn: J. P. Verheyden, J. C. Martin, US 4355032 (1982 to Syntex); K. K. Ogilvie et al., Can. J. Chem. 60, 3005 (1982); W. T. Ashton et al., Biochem. Biophys. Res. Commun. 108, 1716 (1982); J. C. Martin et al., J. Med. Chem. 26, 759 (1983). Antiviral spectrum in vitro: K. O. Smith et al., Antimicrob. Agents Chemother. 22, 55 (1982). Mode of action study: Y.-C. Cheng et al., Proc. Natl. Acad. Sci. USA 80, 2767 (1983). Clinical treatment of cytomegalovirus infection in immunodeficient patients: S. H. Koretz et al., N. Engl. J. Med. 314, 801 (1986). Symposium on pharmacology and clinical efficacy vs cytomegalovirus: Rev. Infect. Dis. 10, Suppl. 3, S457-S572 (1988). Review: C. S. Crumpacker, N. Engl. J. Med. 335, 721-729 (1996).
Properties: Crystals from methanol, mp 250° (dec) (Verheyden, Martin); also reported as crystalline monohydrate from water, mp 248-249° (dec) (Ashton); crystals from water, mp >300° (Martin). uv max (methanol): 254 nm (e 12880). Soly in water (25°): 4.3 mg/ml at pH 7. LD50 i.p. in mice: 1-2 g/kg (Martin).
Melting point: mp 250° (dec) (Verheyden, Martin); mp 248-249° (dec) (Ashton); mp >300° (Martin)
Absorption maximum: uv max (methanol): 254 nm (e 12880)
Toxicity data: LD50 i.p. in mice: 1-2 g/kg (Martin)
 
Derivative Type: Sodium salt
CAS Registry Number: 107910-75-8
Trademarks: Cymevan (Syntex); Cymevene (Syntex); Cytovene (Syntex); Denosine (Syntex); Vitrasert (Chiron)
Molecular Formula: C9H12N5NaO4
Molecular Weight: 277.21
Percent Composition: C 38.99%, H 4.36%, N 25.26%, Na 8.29%, O 23.09%
 
Therap-Cat: Antiviral.
Keywords: Antiviral; Purines/Pyrimidinones.