Home > Name List By other > (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6, 10,13-trimethyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyc... Macao

CAS No 83-43-2 , (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,
10,13-trimethyl-7,8,9,11,12,14,15,
16-octahydro-6H-cyclopenta[a]phenanthren-3-one Search by region : Macao

  • Name: (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,
    10,13-trimethyl-7,8,9,11,12,14,15,
    16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • Synonyms: Medrol; Medrate; Urbason; Metilbetasone; Medesone; Mesopren; Medrone;(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,
    10,13-trimethyl-7,8,9,11,12,14,15,
    16-octahydro-6H-cyclopenta[a]phenanthren-3-one; Dopomedrol; Metastab;
  • CAS Registry Number:
  • Melting Point: 228-237 ºC (DEC.)
  • Density: 1.28
  • Refractive index: 82 ° (C=1, Dioxane)
  • Safety Statements: Moderately toxic by intraperitoneal route. A steroid hormone. Human systemic effects include arrhythmias, blood pressure lowering, heart rate changes, increased body temperature, pulse rate increase, respiratory depression. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Hazard Symbols: Xi
  • EINECS: 201-476-4
  • Molecular Weight: 374.4706
  • InchiKey: VHRSUDSXCMQTMA-PJHHCJLFSA-N
  • InChI: InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,
    3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,
    27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1
  • Risk Statements: S22;S36
  • Molecular Formula: C22H30O5
  • Molecular Structure:CAS No:83-43-2 (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,<br />10,13-trimethyl-7,8,9,11,12,14,15,<br />16-octahydro-6H-cyclopenta[a]phenanthren-3-one

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References of (6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,
10,13-trimethyl-7,8,9,11,12,14,15,
16-octahydro-6H-cyclopenta[a]phenanthren-3-one
Title: Methylprednisolone
CAS Registry Number: 83-43-2
CAS Name: (6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
Synonyms: 1-dehydro-6a-methylhydrocortisone; D1-6a-methylhydrocortisone; 6a-methyl-11b,17a,21-triol-1,4-pregnadiene-3,20-dione
Trademarks: Medrate (Pharmacia & Upjohn); Medrol (Pharmacia & Upjohn); Medrone (Pharmacia)
Molecular Formula: C22H30O5
Molecular Weight: 374.47
Percent Composition: C 70.56%, H 8.07%, O 21.36%
Literature References: Prepn: Spero et al., J. Am. Chem. Soc. 78, 6213 (1956); Fried, ibid. 81, 1235 (1959); Sebek, Spero, US 2897218 (1959 to Upjohn); Gould, US 3053832 (1962 to Schering). Review of clinical toxicology: J. D. Truwit, Crit. Care Clin. 7, 639-657 (1991); of neuroprotective pharmacology: E. D. Hall, J. Neurosurg. 76, 13-22 (1992); of pharmacokinetics and clinical efficacy in multiple sclerosis: O. R. Hommes et al., Mult. Scler. 1, 327-328 (1996). Clinical trial in acute spinal cord injury: M. B. Bracken et al., J. Neurosurg. 89, 699 (1998); in carpel tunnel syndrome: J. W. H. H. Dammers et al., Br. Med. J. 319, 884 (1999).
Properties: Crystals, mp 228-237°. [a]D20 +83° (dioxane). uv max (95% ethanol): 243 nm (aM 14875). Sparingly sol in alcohol, dioxane, methanol; slightly sol in acetone, chloroform; very slightly sol in ether. Practically insol in water.
Melting point: mp 228-237°
Optical Rotation: [a]D20 +83° (dioxane)
Absorption maximum: uv max (95% ethanol): 243 nm (aM 14875)
 
Derivative Type: 21-Acetate
CAS Registry Number: 53-36-1
Trademarks: Depo-Medrol (Pharmacia & Upjohn); Depo-Medrone (Pharmacia); Vetacortyl (V oquinol)
Molecular Formula: C24H32O6
Molecular Weight: 416.51
Percent Composition: C 69.21%, H 7.74%, O 23.05%
Properties: Crystals, mp 205-208°. [a]D20 +101° (dioxane). uv max (95% ethanol): 243 nm (aM 14825). Sol in dioxane; sparingly sol in acetone, alcohol, chloroform, methanol; slightly sol in ether. Practically insol in water.
Melting point: mp 205-208°
Optical Rotation: [a]D20 +101° (dioxane)
Absorption maximum: uv max (95% ethanol): 243 nm (aM 14825)
 
Derivative Type: 21-Succinate sodium salt
CAS Registry Number: 2375-03-3
Trademarks: Solu-Medrol (Pharmacia & Upjohn); Solu-Medrone (Pharmacia)
Molecular Formula: C26H33NaO8
Molecular Weight: 496.53
Percent Composition: C 62.89%, H 6.70%, Na 4.63%, O 25.78%
Properties: White, or nearly white, odorless, hygrosopic, amorphous solid. Very sol in water, alcohol; very slightly sol in acetone. Insol in chloroform.
 
Derivative Type: Aceponate
CAS Registry Number: 86401-95-8
Trademarks: Advantan (Schering AG)
Molecular Formula: C27H36O7
Molecular Weight: 472.57
Percent Composition: C 68.62%, H 7.68%, O 23.70%
 
Therap-Cat: Glucocorticoid.
Therap-Cat-Vet: Glucocorticoid.
Keywords: Glucocorticoid.