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CAS No 84625-59-2 , 1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine Search by region : China

  • Name: 1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
  • Synonyms: Dotarizinum [Latin];1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine; 84625-59-2; 1-(Diphenylmethyl)-4-(3-(2-phenyl-1,3-dioxolan-2-yl)propyl)piperazine; Dotarizina [Spanish];
  • CAS Registry Number:
  • Melting Point: 100-1010C
  • Density: 1.122 g/cm3
  • Refractive index: 1.587
  • Molecular Weight: 442.59246
  • InchiKey: LRMJAFKKJLRDLE-UHFFFAOYSA-N
  • InChI: InChI=1S/C29H34N2O2/c1-4-11-25(12-5-1)28(26-13-6-2-7-14-26)31-21-19-30
    (20-22-31)18-10-17-29(32-23-24-33-29)27-15-8-3-9-16-27/h1-9,11-16,28H,
    10,17-24H2
  • Molecular Formula: C29H34N2O2
  • Molecular Structure:CAS No:84625-59-2 1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine

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84625-59-2 DOTARIZINE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
Contact Supplier

84625-59-2 Dotarizine

  • Dotarizine, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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84625-59-2 Dotarizine

  • Dotarizine, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,China
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84625-59-2 Dotarizine, 99%

  • Dotarizine, 99%
  • China Pleapharma Co.,Ltd [Manufacturer]
  • Tel: 86 23 67030808
  • Fax: 86 23 67030809
  • Address: 22F,Jingxin center,No.70 Xingguang Road,Yubei Zone,Chongqing402232 chongqingCHINA chongqing,China
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84625-59-2 DOTARIZINE

  • China HANGZHOU ONICON CHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-571-85054016/ +86-571-85104679
  • Fax: +86-571-85054082
  • Address: HANGZHOU ONICON CHEMICAL CO.,LTD
    303-306 Hangzhou yiyao Building,
    No.439 Zhongshan North Rd.
    Hangzhou China
    Phone : +86-571-85054016
    Fax: +86-571-85054082
    E-Mail1: cjw9999@163.com ,China
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References of 1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
Title: Dotarizine
CAS Registry Number: 84625-59-2
CAS Name: 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
Manufacturers' Codes: FI-6026
Molecular Formula: C29H34N2O2
Molecular Weight: 442.59
Percent Composition: C 78.70%, H 7.74%, N 6.33%, O 7.23%
Literature References: Mixed calcium channel blocker and serotonin (5-HT2) receptor antagonist. Prepn: R. Foguet et al., EP 97340; eidem, US 4883797 (1984, 1989 both to Ferrer); S. Gubert et al., Arzneim.-Forsch. 37, 1103 (1987). Clinical pharmacokinetics and tolerability: M. Farré et al., Methods Find. Exp. Clin. Pharmacol. 19, 343 (1997). Cerebrovascular study in goats: G. Torregrosa et al., Arzneim.-Forsch. 49, 668 (1999); in rabbits: N. Kuridze et al., J. Neurol. Sci. 175, 13 (2000). Mechanism of blockade: A. Ruiz-Nuno et al., Eur. J. Pharmacol. 411, 289 (2001).
Properties: White crystalline solid from methanol, mp 100-101° (Gubert); also reported as 93-97° (Foguet).
Melting point: mp 100-101° (Gubert); also reported as 93-97° (Foguet)
Therap-Cat: Antimigraine.
Keywords: Calcium Channel Blocker; Piperazine Derivatives; Serotonin Receptor Antagonist; Antimigraine.