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CAS No 84625-59-2 , 1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine Search by region : Swaziland

  • Name: 1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
  • Synonyms: Dotarizinum [Latin];1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine; 84625-59-2; 1-(Diphenylmethyl)-4-(3-(2-phenyl-1,3-dioxolan-2-yl)propyl)piperazine; Dotarizina [Spanish];
  • CAS Registry Number:
  • Melting Point: 100-1010C
  • Density: 1.122 g/cm3
  • Refractive index: 1.587
  • Molecular Weight: 442.59246
  • InchiKey: LRMJAFKKJLRDLE-UHFFFAOYSA-N
  • InChI: InChI=1S/C29H34N2O2/c1-4-11-25(12-5-1)28(26-13-6-2-7-14-26)31-21-19-30
    (20-22-31)18-10-17-29(32-23-24-33-29)27-15-8-3-9-16-27/h1-9,11-16,28H,
    10,17-24H2
  • Molecular Formula: C29H34N2O2
  • Molecular Structure:CAS No:84625-59-2 1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine

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84625-59-2 Piperazine,1-(diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]-

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References of 1-benzhydryl-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
Title: Dotarizine
CAS Registry Number: 84625-59-2
CAS Name: 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
Manufacturers' Codes: FI-6026
Molecular Formula: C29H34N2O2
Molecular Weight: 442.59
Percent Composition: C 78.70%, H 7.74%, N 6.33%, O 7.23%
Literature References: Mixed calcium channel blocker and serotonin (5-HT2) receptor antagonist. Prepn: R. Foguet et al., EP 97340; eidem, US 4883797 (1984, 1989 both to Ferrer); S. Gubert et al., Arzneim.-Forsch. 37, 1103 (1987). Clinical pharmacokinetics and tolerability: M. Farré et al., Methods Find. Exp. Clin. Pharmacol. 19, 343 (1997). Cerebrovascular study in goats: G. Torregrosa et al., Arzneim.-Forsch. 49, 668 (1999); in rabbits: N. Kuridze et al., J. Neurol. Sci. 175, 13 (2000). Mechanism of blockade: A. Ruiz-Nuno et al., Eur. J. Pharmacol. 411, 289 (2001).
Properties: White crystalline solid from methanol, mp 100-101° (Gubert); also reported as 93-97° (Foguet).
Melting point: mp 100-101° (Gubert); also reported as 93-97° (Foguet)
Therap-Cat: Antimigraine.
Keywords: Calcium Channel Blocker; Piperazine Derivatives; Serotonin Receptor Antagonist; Antimigraine.