Home > Name List By other > (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2- yl]prop-2-enoic acid

CAS No 87848-99-5 , (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-
yl]prop-2-enoic acid

  • Name: (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-
    yl]prop-2-enoic acid
  • Synonyms: Acrivastinum; BW-825C;(E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-
    yl]prop-2-enoic acid; Acrivastina [Spanish]; Acrivastinum [Latin]; Acrivastina; BW A825C; Acrivastin; BW 825C;Semprex;
  • CAS Registry Number:
  • Density: 1.17 g/cm3
  • Refractive index: 1.627
  • Molecular Weight: 348.43816
  • InchiKey: PWACSDKDOHSSQD-IUTFFREVSA-N
  • InChI: InChI=1S/C22H24N2O2/c1-17-7-9-18(10-8-17)20(13-16-24-14-2-3-15-24)21-6-
    4-5-19(23-21)11-12-22(25)26/h4-13H,2-3,14-16H2,1H3,(H,25,26)/b12-11+,
    20-13+
  • Molecular Formula: C22H24N2O2
  • Molecular Structure:CAS No:87848-99-5 (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-<br />yl]prop-2-enoic acid

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References of (E)-3-[6-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridin-2-
yl]prop-2-enoic acid
Title: Acrivastine
CAS Registry Number: 87848-99-5
CAS Name: (2E)-3-[6-[(1E)-1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-2-pyridinyl]-2-propenoic acid
Synonyms: (E)-6-[(E)-3-(1-pyrrolidinyl)-1-p-tolylpropenyl]-2-pyridineacrylic acid
Manufacturers' Codes: BW-270C; BW-825C; BW-A825C
Trademarks: Semprex (GSK)
Molecular Formula: C22H24N2O2
Molecular Weight: 348.44
Percent Composition: C 75.83%, H 6.94%, N 8.04%, O 9.18%
Literature References: Nonsedating type histamine H1-receptor antagonist; analog of triprolidine, q.v. Prepn: G. G. Coker, J. W. A. Findlay, EP 85959 (1983 to Wellcome); J. W. A. Findlay, G. G. Coker, US 4501893 (1985). Pharmacodynamics and pharmacokinetics in humans: A. F. Cohen et al., Eur. J. Clin. Pharmacol. 28, 197 (1985). Evaluation of CNS effects: A. F. Cohen et al., Clin. Pharmacol. Ther. 38, 381 (1985). Clinical trials in idiopathic urticaria: J. G. Gibson et al., Dermatologica 169, 179 (1984); H. Neittaanmaki et al., ibid. 177, 98 (1988); in allergic rhinitis: T. G. Gibbs et al., J. Int. Med. Res. 16, 413 (1988). Review of pharmacology and therapeutic efficacy: R. N. Brogden, D. McTavish, Drugs 41, 927-940 (1991).
Properties: Crystals from isopropanol, mp 222° (dec).
Melting point: mp 222° (dec)
NOTE: Combination with pseudoephedrine, Duact (Glaxo Wellcome) .
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Alkylamine Derivatives.