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CAS No 89565-68-4 , Tropisetron

  • Name: Tropisetron
  • Synonyms: 3-Tropanylindole-3-carboxylate;3-tropanylindole-3-carboxylate hydrochloride; 1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester;Tropisetron;
  • CAS Registry Number:
  • Melting Point: 201-202 ºC
  • Density: 1.26
  • Refractive index: 1.644
  • Water Solubility: Soluble in water
  • Safety Statements: Human systemic effects. When heated to decomposition it emits toxic vapors of NOx.
  • Molecular Weight: 284.35
  • InChI: InChI=1/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5,10-13,18H,6-9H2,1H3/t11-,12-/m0/s1
  • Molecular Formula: C17H20N2O2
  • Molecular Structure:CAS No:89565-68-4 Tropisetron

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References of Tropisetron
Title: Tropisetron
CAS Registry Number: 89565-68-4
CAS Name: 1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester
Synonyms: 3a-tropanyl-1H-indole-3-carboxylic acid ester; 1aH,5aH-tropan-3a-yl indole-3-carboxylate
Manufacturers' Codes: ICS-205-930
Molecular Formula: C17H20N2O2
Molecular Weight: 284.35
Percent Composition: C 71.81%, H 7.09%, N 9.85%, O 11.25%
Literature References: Specific serotonin (5-HT3) receptor antagonist. Prepn: P. Donatsch et al., DE 3322574 (1983 to Sandoz); idem et al., US 4789673 (1988). Pharmacology: B. P. Richardson et al., Nature 316, 126 (1985); F. M. Williams et al., J. Cardiovasc. Pharmacol. 7, 550 (1985). Receptor binding studies: C. Waeber et al., Neuroscience 31, 393 (1989). Clinical pharmacokinetics: V. Fischer et al., Drug Metab. Dispos. 20, 603 (1992). Series of articles on antiemetic efficacy in chemotherapy and radiotherapy: Drugs 43, Suppl. 3, 6-39 (1992). Review of pharmacology: C. Seynaeve et al., Anti-Cancer Drugs 2, 343-355 (1991); and toxicology: K. Kutz, Ann. Oncol. 4, Suppl. 3, S15-S18 (1993).
Properties: mp 201-202° (from methylene chloride/ethyl acetate).
Melting point: mp 201-202° (from methylene chloride/ethyl acetate)
 
Derivative Type: Monohydrochloride
CAS Registry Number: 105826-92-4
Trademarks: Navoban (Novartis); Novaban (Novartis)
Molecular Formula: C17H20N2O2.HCl
Molecular Weight: 320.81
Percent Composition: C 63.65%, H 6.60%, N 8.73%, O 9.97%, Cl 11.05%
Properties: mp 283-285° (dec).
Melting point: mp 283-285° (dec)
 
Therap-Cat: Antiemetic.
Keywords: Antiemetic; Serotonin Receptor Antagonist.