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CAS No 9005-49-6 , Heparin

  • Name: Heparin
  • Synonyms: 6-[5-Acetamido-4,6-dihydroxy-2-(sulfooxymethyl)oxan-3-yl]oxy-3-[5-(6-carboxy-4,5-dihydroxy-3-sulfooxyoxan-2-yl)oxy-6-(hydroxymethyl)-3-(sulfoamino)-4-sulfooxyoxan-2-yl]oxy-4-hydroxy-5-sulfooxyoxane-2-carboxylic acid;Heparin;
  • CAS Registry Number:
  • Flash Point: 343.8°C
  • Boiling Point: 644.9°Cat760mmHg
  • Density: 2.18 g/cm3
  • Refractive index: 1.711
  • Water Solubility: Soluble in water, soluble in alcohol, ether, acetone, chloroform and benzene. There hygroscopicity.
  • Safety Statements: Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also HEPARIN SODIUM
  • Hazard Symbols: May cause internal bleeding.
  • Flash Point: 343.8°C
  • EINECS: 232-681-7
  • Molecular Weight: 1134.93
  • InChI: InChI=1S/C27H46O2/c1-18(7-6-14-25(2,3)29)22-10-11-23-21-9-8-19-17-20(28)12-15-26(19,4)24(21)13-16-27(22,23)5/h8,18,20-24,28-29H,6-7,9-17H2,1-5H3/t18-,20+,21+,22-,23+,24+,26+,27-/m1/s1
  • Molecular Formula: C26H42N2O37S5
  • Molecular Structure:CAS No:9005-49-6 Heparin
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9005-49-6 ENOXAPARIN SODIUM

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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9005-49-6 Heparin

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9005-49-6 Heparin

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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9005-49-6 Heparin

  • India Triveni Chemicals []
  • Tel: +91-(260)-2400022, 3258683
  • Fax: +91-(260)-2400022/3264008
  • Address: 135, Pancharatna, Char Rasta, G.I.D.C., Vapi, Gujarat 396 195, ,India
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9005-49-6 HEPARIN

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
  • Tel: +86-571-81956191/ +86-571-81956192
  • Fax: +86-571-81956190
  • Address: 425 MOGAN HILL ROAD ,
    HANGZHOU, 310011 CHINA ,China
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9005-49-6 HEPARIN

  • China SINOCO CHEMICAL CO., LIMITED [Importer/Exporter]
  • Tel: +86-571-81956191, 81956192
  • Fax: 86-571-81956190 88386326
  • Address: 425 Ruiqi Mansion Moganshan Road , Hangzhou 310011 China. Hangzhou,ZhejiangChina
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9005-49-6 Heparin

  • China ZIBO EASTMARK TRADE CO.,LTD [Importer/Exporter]
  • Tel: +86 533 5160706
  • Fax: +86 533 5160707
  • Address: 1117, Hongtai Bld., Songling rd, Zichuan,Zibo,Shandong,China zibo,shandongChina
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References of Heparin
Title: Heparin
CAS Registry Number: 9005-49-6
Synonyms: Heparinic acid
Trademarks: Arteven (Boehringer, Ing. Italia); Leparan (Italfarmaco)
Literature References: Glycosaminoglycan with anticoagulant activity. Heterogenous mixture of variably sulfated polysaccharide chains composed of repeating units of D-glucosamine and either L-iduronic or D-glucuronic acids. Mol wt ranges from 6000-30000 Da. Biosynthesized and stored in mast cells of various animal tissues, particularly liver, lung or gut. Commercial heparin is isolated from beef lung or pork intestinal mucosa. Isoln from mammalian tissue: Howell, Am. J. Physiol. 63, 434 (1922-23); 71, 553 (1924-25); Korn, J. Biol. Chem. 234, 1325 (1959); L. B. Jaques, Can. J. Biochem. Physiol. 37, 1183 (1959); J. A. Bush et al., US 2884358 (1959 to So. Calif. Gland). Purification: G. Nominé et al., US 2989438 (1961 to UCLAF); Toccaceli, US 3016331 (1962 to Ormonoterapia Richter); L. Roden et al., Methods Enzymol. 26, 73 (1972). Structural studies: M. L. Wolfrom, J. Am. Chem. Soc. 72, 5796 (1950); Velluz et al., Compt. Rend. 247, 1521 (1958); M. L. Wolfrom et al., J. Org. Chem. 29, 540 (1964). Configuration of glycosidic linkages: M. L. Wolfrom et al., ibid. 31, 1173 (1966); A. S. Perlin et al., Can. J. Chem. 48, 2260 (1970); T. Helting, U. Lindahl, J. Biol. Chem. 246, 5442 (1971). Identification of L-iduronic acid residues: A. S. Perlin et al., Carbohydr. Res. 7, 369 (1968). Antithrombotic activity results from the binding and activation of antithrombin III, a plasma protein which inhibits several enzymes in the coagulation cascade: R. D. Rosenberg, Fed. Proc. 36, 10 (1977). Anticoagulant activity is related to the mol wt of the polysaccharide fragments; low molecular weight components exhibit decreased hemorrhagic effects while retaining antithrombin binding ability: L.-O. Andersson et al., Thromb. Res. 15, 531 (1979); T. W. Barrowcliffe et al., Br. J. Haematol. 41, 573 (1979); J. Hirsch et al., Semin. Thromb. Hemostasis 11, 13 (1985). Characterization of the antithrombin binding site: U. Lindahl et al., Proc. Natl. Acad. Sci. USA 76, 3198 (1979); J. Choay et al., Thromb. Res. 18, 573 (1980). Synthesis of the pentasaccharide corresponding to the binding site sequence: eidem, Biochem. Biophys. Res. Commun. 116, 492 (1983). Symposium on structure, activity and clinical applications: Fed. Proc. 36, 9-116 (1977). Review of mechanism of action: I. Bj?rk, U. Lindahl, Mol. Cell. Biochem. 48, 161-182 (1982); of structure-activity relationships and prepn of low mol wt fractions: B. Casu, Adv. Carbohydr. Chem. Biochem. 43, 51-134 (1985); of biosynthesis: U. Lindahl et al., Trends Biochem. Sci. 11, 221-225 (1986). Comprehensive description: F. Nachtmann et al., Anal. Profiles Drug Subs. 12, 215-276 (1983). Overview of clinical results in pulmonary embolism and venous thrombosis: R. Collins et al., N. Engl. J. Med. 318, 1162-1170 (1988); J. Hirsh, ibid. 324, 1565-1574 (1991); of clinical studies with low mol wt heparinoids: H. ten Cate et al., Am. J. Hematol. 27, 146-153 (1988).
Properties: Heparin has a rotation of [a]D20 +55°.
Optical Rotation: [a]D20 +55°
 
Derivative Type: Calcium salt
CAS Registry Number: 37270-89-6
Trademarks: Calciparine (Sanofi Winthrop); Ecasolv (Lepetit)
 
Derivative Type: Magnesium salt
CAS Registry Number: 54479-70-8
Synonyms: Magnesium heparinate
Trademarks: Cutheparine (Biosedra)
Properties: Sol in water. Insol in organic solvents.
 
Derivative Type: Potassium salt
CAS Registry Number: 9005-48-5
Trademarks: Clarin (formerly) (Pfizer)
 
Derivative Type: Sodium salt
CAS Registry Number: 9041-08-1
Synonyms: Heparin sodium
Trademarks: Hepsal (Weddel); Lipo-Hepin (3M Pharma); Liquémin (Roche); Longheparin; Monoparin (CP Pharm.); Panheprin (Abbott); Pularin; Liquaemin Sodium (Organon); Minihep (Leo Pharm); Thromboliquine; Thrombophob (Nordmark); Unihep (Leo Pharm)
Properties: White to grayish-brown amorphous powder. Odorless, hygroscopic. [a]D25 +47° (c = 1.5 in water). One gram dissolves in 20 ml water. Sol in saline soln. Practically insol in alcohol, acetone, benzene, chloroform, ether. pH of 1% aq soln = 6.0 to 7.5. Absorption spectrum: Burson et al., J. Am. Chem. Soc. 78, 5874 (1956). Ampuled solns may be stored at room temp for at least 12 months. Commercially available ampuled, sterile solns contain 0.5% phenol or chlorobutanol as preservative.
Optical Rotation: [a]D25 +47° (c = 1.5 in water)
 
Therap-Cat: Anticoagulant.
Therap-Cat-Vet: Anticoagulant.
Keywords: Anticoagulant.