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CAS No 9039-53-6 , Urokinase

  • Name: Urokinase
  • Synonyms: Urokinase;Urokinase plasminogen activator;-;
  • CAS Registry Number:
  • Safety Statements: An experimental teratogen. Experimental reproductive effects. Used in the treatment of diseases caused by blood clots.
  • Hazard Symbols: B
  • EINECS: 232-917-9
  • Molecular Weight: 0
  • InChI: InChI=1S/C14H14N4O2S/c1-8(2)20-14(19)16-9-3-4-10-11(5-9)18-13(17-10)12-6-21-7-15-12/h3-8H,1-2H3,(H,16,19)(H,17,18)
  • Molecular Formula: C21H25BrN2O3
  • Molecular Structure:CAS No:9039-53-6 Urokinase
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9039-53-6 UROKINASE

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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9039-53-6 Urokinase

  • China Qingdao Chinaoil Co., Ltd []
  • Fax: +86-532-85713888 85723888
  • Address: 22/F,Golden Light Tower,No.56, Xianggang Zhong Road, Qingdao 266071, China ,China
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9039-53-6 Urokinase

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9039-53-6 UROKINASE

  • China IFFECT CHEMPHAR CO., LTD. []
  • Tel: 0086 755-83761619 83760606
  • Fax: +86-25- 84270111
  • Address: 15A,Changfa Center, Building B ,No. 300,East Zhongshan Road,Baixia District,Nanjing,210002, P.R.China. Nanjing,JiangshuChina
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9039-53-6 Urokinase

  • China Saniver Limited []
  • Fax: +86-21-62882088 +86-852-23333065
  • Address: 805 Harbour Centre, Tower 2, 8 Hok Cheung St., Hunghom, Kowloon, Hong Kong. ,China
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9039-53-6 UROKINASE

  • China FAITH EAGLE (LABORATORY) LTD. [Manufacturers]
  • Tel: (+86-755) 82851290
  • Fax: +86-755-83164680 83662918
  • Address: 15A/F.,Block A,World Trade Plaza,8# FuHong Rd., FuTian,Shenzhen, China Shenzhen,GuangdongChina
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9039-53-6 Urokinase

  • China Inter-Chemical Ltd. [Manufacturers]
  • Tel: +86-(755)-82187211, 82192202
  • Fax: +86-(755)-82187212
  • Address: B-1108/1109, Tian An International Bldg., RenMin Nan Road, ShenZhen 518005, Shenzhen,GuangdongChina
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9039-53-6 Urokinase

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9039-53-6 Urokinase

  • United States NetQem [Importer/Exporter]
  • Tel: +1-919-3047991
  • Fax: +1-919-3046567
  • Address: P.O. Box 12091, Research Triangle Park, NC 27709 Research Triangle Park,NCUnited States
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9039-53-6 Urokinase

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References of Urokinase
Title: Urokinase
CAS Registry Number: 9039-53-6
Manufacturers' Codes: Win-22005
Trademarks: Abbokinase (Abbott); Actosolv (HMR); Breokinase (Sanofi Winthrop); Persolv (Lepetit); Purochin (Sclavo); Ukidan (Serono); Uronase (Mochida); Win-Kinase (Winthrop)
Literature References: Serine protease which activates plasminogen to plasmin; present in mammalian blood and urine. Produced as prourokinase, q.v., and converted to active form by plasmin or kallikrein, q.q.v. Description of fibrinolytic activity: J. R. B. Williams, Br. J. Exp. Pathol. 32, 530 (1951). Isolation from human urine and activity: T. Astrup, I. Sterndorff, Proc. Soc. Exp. Biol. Med. 81, 675 (1952); G. W. Sobel et al., Am. J. Physiol. 171, 768 (1952). Species specificity and distribution in mammals: S. R. Mohler et al., Am. J. Physiol. 192, 186 (1958). Isoln from human male urine: H. O. Singher, L. Zuckerman, US 2961382 and US 2989440 (1960, 1961 to Ortho); N. O. Kjeldgaard, J. Ploug, US 2983647 (1961 to L?vens Kemiske Fabrik); J. Doczi, US 3081236 (1963 to Warner-Lambert). Prepn of crystalline form: A. Lesuk et al., Science 147, 880 (1965). Two variants of bioactive urokinase, high molecular weight (HMW-UK, ~50 KDa) and low molecular weight (LMW-UK, ~30 KDa) have been identified: W. F. White et al., Biochemistry 5, 2160 (1966). Both are disulfide-linked dimers consisting of a heavy chain (B) and a light chain (A). HMW-UK is converted to LMW-UK by proteolytic cleavage of the A-chain to form the A1-chain. Series of articles on plasminogen activation, fibrinolysis and clinical efficacy: Proc. Serono Symp., Thrombosis and Urokinase 9, 1-257 (1977). Review: F. Duckert, Handb. Exp. Pharmacol. 46, 209-237 (1978). Structural characterization: M. Nobuhara et al., J. Biochem. 90, 225 (1981). Structure and amino acid sequences: W. A. Günzler et al., Z. Physiol. Chem. 363, 133 (1982); G. J. Steffens et al., ibid. 1043; W. A. Günzler et al., ibid. 1155. Expression of gene coding for human urokinase in E. coli: B. Ratzkin et al., Proc. Natl. Acad. Sci. USA 78, 3313 (1981). Clinical evaluation in pulmonary embolism: P. Petitpretz et al., Circulation 70, 861 (1984). Clinical trial following myocardial infarction: H. Kambara et al., Jpn. Circ. J. 51, 1072 (1987). Clinical applications of urokinase-treated tubing: T. Ohshiro et al., Methods Enzymol. 137, 529 (1988). Literature review of thrombolytic therapy: J. A. Kaufman, M. A. Bettmann, Semin. Intervent. Radiol. 9, 159-165 (1992).
Therap-Cat: Thrombolytic.
Keywords: Thrombolytic.