CAS No 95233-18-4 , 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione Search by region : India

Name: 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione
Synonyms: 95233-18-4; Acuvel; 566C;3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione;Wellvone; Mepron (antipneumocystic); 566C80; Malarone Pediatric; Malarone; Mepron;
CAS Registry Number:95233-18-4
Density: 1.349g/cm3
Refractive index: 1.653
Molecular Weight: 366.83746
InchiKey: BSJMWHQBCZFXBR-UHFFFAOYSA-N
InChI: InChI=1S/C22H19ClO3/c23-16-11-9-14(10-12-16)13-5-7-15(8-6-13)19-20(24)
17-3-1-2-4-18(17)21(25)22(19)26/h1-4,9-13,15,24H,5-8H2
Molecular Formula: C₂₂H₁₉ClO₃
Molecular Structure:

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References of 3-[4-(4-chlorophenyl)cyclohexyl]-4-hydroxynaphthalene-1,2-dione

Title: Atovaquone
CAS Registry Number: 95233-18-4
CAS Name: 2-[trans-4-(4-Chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthalenedione
Synonyms: trans-2-[4-(4-chlorophenyl)cyclohexyl]-3-hydroxy-1,4-naphthoquinone
Manufacturers' Codes: 566C80; BW-566C; BW-566C-80
Trademarks: Mepron (GSK); Wellvone (GSK)
Molecular Formula: C22H19ClO3
Molecular Weight: 366.84
Percent Composition: C 72.03%, H 5.22%, Cl 9.66%, O 13.08%
Literature References: Hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Prepn: A. T. Hudson, A. W. Randall, EP 123238; eidem, US 5053432 (1984, 1991 both to Burroughs Wellcome). Antiprotozoal activity, metabolism, and pharmacokinetics: A. T. Hudson et al., Drugs Exp. Clin. Res. 17, 427 (1991). Mechanism of action study: M. Fry, M. Pudney, Biochem. Pharmacol. 43, 1545 (1992). Clinical trial for prevention of pneumocystis pneumonia in AIDS patients: W. M. El-Sadr et al., N. Engl. J. Med. 339, 1889 (1998).
Properties: Crystals from acetonitrile, mp 216-219°. Practically insol in water.
Melting point: mp 216-219°
Therap-Cat: Antipneumocystic.
Keywords: Antipneumocystic.