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CAS No 96-88-8 , 2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-methyl-

  • Name: 2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-methyl-
  • Synonyms: Scandicain;22801-44-1;DL-Mepivacaine;1-Methyl-2',6'-pipecoloxylidide;Carbocain;Carbocaine-V;2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-methyl-;2',6'-Pipecoloxylidide,1-methyl- (6CI,8CI);Mepivacaine;Tevacaine;Scandicaine;Carbocaine;Mepicaine;
  • CAS Registry Number:
  • Safety Statements: Poison by intravenous route. Moderately toxic by subcutaneous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • EINECS: 202-543-0
  • Molecular Weight: 246.34798
  • InChI: InChI=1S/C15H22N2O/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18)
  • Molecular Formula: C15H22N2O
  • Molecular Structure:CAS No:96-88-8 2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-methyl-

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96-88-8 DL-1-METHYL-2'',6''-PIPECOLINOXYLIDIDE(MEPIVACAINE BASE)

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96-88-8 DL-1-METHYL-2'',6''-PIPECOLINOXYLIDIDE(MEPIVACAINE BASE)

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References of 2-Piperidinecarboxamide,N-(2,6-dimethylphenyl)-1-methyl-
Title: Mepivacaine
CAS Registry Number: 96-88-8
CAS Name: N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide
Synonyms: 1-methyl-2￠,6￠-pipecoloxylidide; dl-N-methylpipecolic acid 2,6-dimethylanilide; dl-N-methylhexahydropicolinic acid 2,6-dimethylanilide
Molecular Formula: C15H22N2O
Molecular Weight: 246.35
Percent Composition: C 73.13%, H 9.00%, N 11.37%, O 6.49%
Literature References: Prepn: Ekenstam et al., Acta Chem. Scand. 11, 1183 (1957); US 2799679 (1957 to A. B. Bofors). Prepn of other salts: Rinderknecht, Helv. Chim. Acta 42, 1324 (1959); GB 826668 (1960 to Crookes Labs.). Resolution of isomers: Tullar, J. Med. Chem. 14, 891 (1971); Friberger, Aberg, Acta Pharm. Suec. 8, 361 (1971). Pharmacology: Helmy et al., J. Egypt. Med. Assoc. 50, 688 (1967). Metabolism: Reynolds, Br. J. Anaesth. 43, 33 (1971). Toxicity data: G. Aberg, Acta Pharmacol. Toxicol. 31, 273 (1972).
Properties: Crystals from ether, mp 150-151°.
Melting point: mp 150-151°
 
Derivative Type: Hydrochloride
CAS Registry Number: 1722-62-9
Trademarks: Carbocaina (Astra); Carbocaine hydrochloride (Winthrop); Chlorocain (Pharm. Mfg.); Meaverin (Woelm); Mepicaton (Pharmaton); Mepident (Parke-Davis); Mepivastesin (Espe); Optocain (Bayer); Scandicain (Bofors)
Molecular Formula: C15H22N2O.HCl
Molecular Weight: 282.81
Percent Composition: C 63.70%, H 8.20%, N 9.91%, O 5.66%, Cl 12.54%
Properties: mp 262-264°. Sol in water. LD50 in mice, rats (mg/kg): 280, 500 s.c. (Aberg).
Melting point: mp 262-264°
Toxicity data: LD50 in mice, rats (mg/kg): 280, 500 s.c. (Aberg)
 
Derivative Type: (+)-Form
Synonyms: Dexivacaine
 
Therap-Cat: Anesthetic (local).
Therap-Cat-Vet: Anesthetic (local).
Keywords: Anesthetic (Local).