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CAS No 96187-53-0 , Brequinar

  • Name: Brequinar
  • Synonyms: Brequinar;6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid;
  • CAS Registry Number:
  • Flash Point: 287°C
  • Boiling Point: 550.9°Cat760mmHg
  • Density: 1.319g/cm3
  • Refractive index: 1.644
  • Flash Point: 287°C
  • Molecular Weight: 375.3675
  • InChI: InChI=1/C23H15F2NO2/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25/h2-12H,1H3,(H,27,28)
  • Molecular Formula: C23H15F2NO2
  • Molecular Structure:CAS No:96187-53-0 Brequinar

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References of Brequinar
Title: Brequinar
CAS Registry Number: 96187-53-0
CAS Name: 6-Fluoro-2-(2￠-fluoro[1,1￠-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid
Molecular Formula: C23H15F2NO2
Molecular Weight: 375.37
Percent Composition: C 73.59%, H 4.03%, F 10.12%, N 3.73%, O 8.52%
Literature References: Inhibitor of dihydroorotate dehydrogenase, the fourth enzyme in the de novo pyrimidine biosynthetic pathway; depresses lymphocyte proliferation. Prepn: D. P. Hesson, EP 133244; idem, US 4680299 (1985, 1987 both to DuPont). Mechanisms of action: T. L. Forrest et al., Transplantation 58, 920 (1994). Clinical pharmacokinetics: M. de Forni et al., Eur. J. Cancer 29A, 983 (1993). Symposium on pharmacology, toxicology: Transplant. Proc. 25, Suppl. 2, 1-83 (1993). Review of development and clinical experience: L. Makowka et al., Immunol. Rev. 136, 51-70 (1993).
Properties: White crystals from DMF + water, mp 315-317°.
Melting point: mp 315-317°
 
Derivative Type: Sodium salt
CAS Registry Number: 96201-88-6
Manufacturers' Codes: DUP-785; NSC-368390
Molecular Formula: C23H14F2NNaO2
Molecular Weight: 397.35
Percent Composition: C 69.52%, H 3.55%, F 9.56%, N 3.53%, Na 5.79%, O 8.05%
Properties: White solid, mp >360°. Sol in water.
Melting point: mp >360°
 
Therap-Cat: Immunosuppressant.
Keywords: Immunosuppressant.