Home > Name List By 6 > 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3- carboxylic acid

CAS No 98106-17-3 , 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-
carboxylic acid

  • Name: 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-
    carboxylic acid
  • Synonyms: Difloxacin [INN]; 98106-17-3;6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-
    carboxylic acid; Difloxacin (INN);
  • CAS Registry Number:
  • Flash Point: 313.9 ºC
  • Boiling Point: 595.5 ºC at 760 mmHg
  • Density: 1.409 g/cm3
  • Flash Point: 313.9 ºC
  • Molecular Weight: 399.390666
  • InchiKey: NOCJXYPHIIZEHN-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H19F2N3O3/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)
    16(21(28)29)12-26(18)14-4-2-13(22)3-5-14/h2-5,10-12H,6-9H2,1H3,(H,28,29)
  • Molecular Formula: C21H19F2N3O3
  • Molecular Structure:CAS No:98106-17-3 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-<br />carboxylic acid

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References of 6-fluoro-1-(4-fluorophenyl)-7-(4-methylpiperazin-1-yl)-4-oxoquinoline-3-
carboxylic acid
Title: Difloxacin
CAS Registry Number: 98106-17-3
CAS Name: 6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
Molecular Formula: C21H19F2N3O3
Molecular Weight: 399.39
Percent Composition: C 63.15%, H 4.80%, F 9.51%, N 10.52%, O 12.02%
Literature References: Fluoroquinolone antibacterial structurally related to norfloxacin, q.v. Prepn: D. T. W. Chu, EP 131839; idem, US 4730000 (1985, 1988 both to Abbott); D. T. W. Chu et al., J. Med. Chem. 28, 1558 (1985); H. Narita et al., JP Kokai 85 237069 (1985 to Toyama). Antibacterial spectrum in vitro: J. M. Stamm et al., Antimicrob. Agents Chemother. 29, 193 (1986); in vivo: P. B. Fernandes et al., ibid. 201. Activity vs anaerobic bacteria: eidem, J. Antimicrob. Chemother. 18, 693 (1986). HPLC determn in biological fluids: G. R. Granneman, L. T. Sennello, J. Chromatogr. 413, 199 (1987). Pharmacokinetics in humans: G. R. Granneman et al., Antimicrob. Agents Chemother. 30, 689 (1986).
 
Derivative Type: Monohydrochloride
CAS Registry Number: 91296-86-5
Manufacturers' Codes: Abbott 56619; A-56619
Trademarks: Dicural (Fort Dodge)
Molecular Formula: C21H19F2N3O3.HCl
Molecular Weight: 435.85
Percent Composition: C 57.87%, H 4.63%, F 8.72%, N 9.64%, O 11.01%, Cl 8.13%
Properties: Crystals, mp >275°.
Melting point: mp >275°
 
Therap-Cat-Vet: Antibacterial.