Methapharm manufactures and distributes Provocholine? (methacholine chloride powder for inhalation) indicated for the diagnosis of bronchial airway hyperactivity in subjects who do not have clinically apparent asthma. Provocholine is supplied as 100 mg of methacholine chloride in 20 mL amber vials (packaged in boxes of six vials). Provocholine? is an approved product with the U.S. Food & Drug Administration (FDA), the Canadian Therapeutic Products Directorate (TPD), and the health authorities of a number of other jurisdictions. In addition to Provocholine, Methapharm also supplies custom kits with all of the necessary components for bronchial challenge testing for multi-centre clinical studies.