Profile: Knowshine (Shanghai) Pharmachemicals Inc. specializes in developing & producing anti-cancer APIs and intermediates. Irinotecan hydrochloride trihydrate is a derivative of camptothecin. It is a pale yellow to yellow crystalline powder. It is soluble in water, methanol, sparingly soluble in chloroform and insoluble in acetone. It is used for the treatment of metastatic colorectal cancer. Docetaxel trihydrate is a white or off-white crystalline powder as a natural anticancer agent, soluble in methanol, ethanol, DCM, DMSO and barely insoluble in water. It is used for the treatment of patients with locally advanced or metastatic breast cancer after failure of prior chemotherapy.