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  • Company Name: Hangzhou LedunTechnology Co.,Ltd.
  • Street: ROOMA1903, Building NO.2, High-tech Business Incubator, the 6th Street, No. 452, Xiasha Economic&Technological Development Area
  • City: Hangzhou
  • Province/state: Zhejiang
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Laropiprant

  • CAS No:571170-77-9 mk 0524
    Molecular Structure

    Detailed Description

    Laropiprant(Cardaptive; MK 0524) is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 muM for the DP1 and DP2 receptors, respectively. Laropiprant(Cardaptive; MK 0524) inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively. In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion. At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a murine model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.