PROCAINE

• Product NamePROCAINE
  CAS No.59-46-1
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Detailed Description

Specifications

Sterile suspension Procaine penicillin g &Dihydrostreptomycin Injection
Specification 20:20 / 20:25
GMP Standard

Product name Procaine penicillin G and Dihydrostreptomycin sulphate Injection
Specification 20:20 /20:25
COMPOSITION:
Contains per ml:
Procaine penicillin G 200 000 IU.
Dihydrostreptomycin sulphate 200 mg.


Each ml contains:

Procaine Benzylpenicillin (procaine penicillin).......................200 mg

Dihydrostreptomycin-Sulphate ................................................. 250 mg

The product also contains nipasept sodium as antimicrobial preservative and sodium formaldehyde sulphoxylate dihydrate as antioxidant.


DESCRIPTION:

The combination of procaine penicillin G and dihydrostreptomycin acts additive and in some cases synergistic. Procaine penicillin G is a small-spectrum penicillin with a bactericidal action against mainly Gram-positive bacteria like Campylobacter, Clostridium, Corynebacterium, Erysipelothrix, Haemophilus, Listeria, Pasteurella, penicillinase negative Staphylococcus and Streptococcus spp. Dihydrostreptomycin is an aminoglycoside with a bactericidal action against mainly Gram-negative bacteria like E. coli, Klebsiella, Pasteurella, Salmonella and Staphylococcus spp.

INDICATIONS:

Arthritis, mastitis and gastrointestinal, respiratory and urinary tract infections caused by penicillin and dihydrostreptomycin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Klebsiella, Listeria, Pasteurella, Salmonella, Staphylococcus and Streptococcus spp., in calves, cattle, goats, sheep and swine.

DOSAGE AND ADMINISTRATION:

For intramuscular administration: 20:20
Cattle : 1 ml. per 20 kg. body weight for 3 days.
Calves, goats, sheep and swine : 1 ml. per 10 kg. body weight for 3 days.
Shake well before use and do not administer more than 20 ml. in cattle, more than 10 ml. in swine and more than 5 ml. in calves, sheep and goats per injection site.


Administered by deep intramuscular injection.20:25

Normal aseptic precautions should be observed.

Recommended dosage rate is 8mg/kg bodyweight procaine penicillin with 10mg/kg bodyweight dihydrostreptomycin sulphate equivalent to 1ml per 25kg bodyweight. Treatment should be given once daily for up to three consecutive days. The maximum dose volume administered at one site should not exceed 15 ml for horses, 6ml for cattle, 3ml for sheep and 1.5ml for pigs.


CONTRAINDICATIONS:

- Hypersensitivity to penicillin, procaine and/or aminoglycosides.
- Administration to animals with a serious impaired renal function.
- Concurrent administration with tetracyclines, chloramphenicol, macrolides and lincosamides.

SIDE EFFECTS:

- Administration of therapeutic dosages of procaine penicillin G can result in abortion in sows.
- Ototoxity, neurotoxicity or nephrotoxicity.
- Hypersensitivity reactions.
WITHDRAWAL TIMES:
- For kidney : 45 days.
- For meat : 21 days.
- For milk : 3 days.
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• PROCAINE