Isotretinoin
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Molecular Structure
Detailed Description
Isotretinoin
Synonyms: 13-cis-ra;13-cis-retinoicaci;13-ra;accutane;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780
CAS: 4759-48-2
MF: C20H28O2
MW: 300.44
EINECS: 225-296-0
Product Categories: Antibiotics;Organic acids;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids
Chemical Properties: Yellow-Orange Crystalline Powder
Usage: Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
Air & Water Reactions: Insoluble in water.
Packing:100g/foil bag
ITEMS STANDARDS RESULTS
Appearance A white to off white powder White powder
Identification A. Meets the requirement Complies
B. IR: similar to Reference Substance Complies
Loss on drying ≤0.5% 0.21%
Specific Rotation +10.0°~+13.0° +10.8°
Related Substances Any single impurity ?ü0.1% Total impurity ?ü0.8% 0.05% 0.10%
Purity By HPLC R-isomer ≤0.15% 0.10
Residue on ignition ≤0.1% 0.05%
Residual solvents Isopropyl alcohol ?ü5000ppm Ethyl Acetate ≤5000ppm 150ppm 250ppm
Heavy metals ≤10ppm Complies
Chlorides ≤0.05% Complies
Assay 98%~102.0% 99.8%
Conclusion Analyse according to Factory Standard , Conform
- Isotretinoin
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