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依米丁

产品名称: 依米丁
CAS Registry Number: 483-18-1
EINECS: 207-592-1  
别名: 吐根碱;依米丁;
分子结构:
分子式: C29H40N2O4
分子量: 480.6389
密度:  1.17g/cm3
沸点:  600.3°Cat760mmHg
闪点:  316.9°C
安全声明:  A human poison by an unspecified route. An experimental poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. Human systemic effects by subcutaneous route: muscle weakness, cardiac arrhythmias, and gastrointestinal effects. Mutation data reported. A severe eye and moderate skin irritant. It is one of the two potent alkaloids obtained from the Brazilian plant ipecac. The therapeutic use of various ipecac preparations has caused many cases of poisoning, in some instances with fatal results. The toxic effects are particularly prominent if the drug is given intravenously. The symptoms of intoxication are gastrointestinal irritation and salivation, as well as general edema, which follows renal insufficiency, hemoptysis (blood-stained sputum), flaccid paralysis, peripheral neuritis (inflammation of the nerve endings), aphonia (loss of voice), difficulties in swallowing, delirium, coma, and failure of the heart. The fatal dose is considered to be approximately 2 g, whether administered over a short or relatively long period. The drug seems to have a cumulative effect. When heated to decomposition it emits highly toxic fumes of NOx.
危险品标志:  Toxic by ingestion.

其他产品

依米丁相关信息

性状

  注射液。

功能主治

  本品能杀灭溶织阿米巴滋养体,适用于急性阿米巴痢疾急需控制症状者。本品还可用于蝎子螫伤。

用法及用量

  1.治阿米巴痢:体重在60kg以下者按每日每千克体重1mg计(60kg以上者,剂量仍按60kg计),每日1次或分2次作深部皮下注射,连用6-10日为1疗程。如未愈,30日后再用第2疗程。2.治蝎子螫伤:以本品3%-6%注射液少许,注入螫孔内即可。

药理毒理

  依米丁对阿米巴原虫滋养体有直接杀灭作用,但对其包囊则无效。其作用是通过抑制肽链的延长,而使寄生虫和哺乳动物细胞中的蛋白质合成受阻。依米丁只能杀死肠壁及组织中的滋养体,而不能消灭肠腔中的滋养体。

药代动力学

  依米丁注射后药物分布在肝、肺、肾及脾,而以肝内为最高。主要由肾脏排泄,自肠粘膜随粪便排出的量极少。由于此药的排泄很慢,停药后40―60天仍继续排泄药物,所以易发生蓄积作用。

不良反应和注意

  1.本品排泄缓慢,易蓄积中毒,不宜长期连续使用对人的致死量为每千克体重10-20mg。用药后期多出现不良反应,常见的有恶心、呕吐、腹痛、腹泻、肌无力等,偶见周围神经炎(注射前静注10%葡萄糖酸钙10ml可减轻副反应)。对心肌损害可表现为血压下降,心前区痛、脉细弱、心律失常、心力衰竭等。如有心电图变化,应立即停药,否则易致急性心肌炎而引起死亡。2.重症心脏病、高度贫血、肝肾功能明显减退者、即将手术的病人、老弱病人、孕妇与幼婴儿均禁用。

其他

  规格:注射液:每支30mg(1ml)、60mg(1ml)。
  生产厂家:
  是否医保用药:医保
  是否非处方药:处方