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Dorsomorphin (dihydrochloride)

  • Purity: >98%
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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Item specifics

  • Product Name.:Dorsomorphin (dihydrochloride)
  • CAS No: 1219168-18-9

Details

Dorsomorphin (dihydrochloride)Dorsomorphin 2Hcl (Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3), and BMPR-IB (ALK 6).

IC50 value: 109 nM (Ki for AMPK)

Target: AMPK

in vitro: Compound C treatment of MCF7 cells led to Bax redistribution from the cytoplasm to mitochondria and cell death.ceramide synthase 5 (LASS/CerS 5) is involved in Compound C-induced ceramide upregulation.

Target:VD_VDR

Product Links:http://www.medchemexpress.cn/dorsomorphin-dihydrochloride.html

Permanent link:http://www.medchemexpress.com/dorsomorphin-dihydrochloride.html

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