Erlotinib hydrochloride
Synonyms:Erlotinib, Hydrochloride Salt;N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, Hydrochloride Salt, OSI 774, Tarceva; N-(3-Ethynylphenyl)-6,7-bis-(2-methoxyethoxy)-quinazolin-4-amine;[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4yl]-(3-ethynyl-phenyl)-amine
CAS:183319-69-9
MF:C22H24ClN3O4
MW:429.9
Product Categories:Molecular Targeted Antineoplastic;anti-neoplastic;Heterocycles;Pharmaceuticals;Tarceva;Antineoplastic;Anti-cancer&immunity
Chemical Properties: Off-White Solid
Assay:99%
Usage:Selective epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor. Erlotinib HCl (OSI-744) is an EGFR inhibitor with IC50 of 2 nM, >1000-fold more sensitive for EGFR than human c-Src or v-Abl. Phase 3.
Packing: 1kg/foil bag or as required
Item of analysisStandardResult of analysis
DescriptionWhite to pale yellow powderConforms
Melting piont215.0-227.0℃219.0-220.0℃
IdentificationA: IRConresponding to reference spectrumConresponding to reference spectrum
B : HPLCConresponding to reference RTConresponding to reference RT
Loss on drying≤0.5%0.31%
Residual on lgnition≤0.5%0.19%
Residual solventpyridine≤4000ppmND
DMF?ü3000ppmND
Chloroform?ü4000ppmND
Ordinary impuritiesTotal impurities≤2.0%0.30%
Assay98.0%～101.0%99.7%
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