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ACADESINE

  • CAS No.: 2627-69-2
  • Purity: 99% min.
  • Min quantity: 5200 Kilograms
  • Price: USD 1~2/Kilograms
  • Place of Orign: zhuzhou,Hunan,China
Ms.dan Amy

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Item specifics

  • Product Name.:ACADESINE
  • CAS No: 2627-69-2
  • Weight: 258.23
  • Formula: C9H14 N4 O5
  • Melting Point: 214-215 ºC
  • Boiling Point: 726.3 °C at 760 mmHg
  • Density: 2.06 g/cm3

Details

ACADESINE

Alias: AICAR;
AICA-RIBOSIDE;
AMPK;
Z-RIBOSIDE

CAS: 2627-69-2
EINECS: 220-097-5
M.F.: C9H14N4O5
M.W.: 258.23
M.S.:

M.P.: 214-215 °C

adenosine regulating agents:Acadesine is the prototype of a new class of compounds termed adenosine regulating agents. Acadesine is a purine nucleosid analogue that enters the myocyte and is immediately phosphorylated to ZMP (AICA ribotide), which is further metabolised to Inosine mono-phosphate (an intermediate in the synthesis ofadenosine triphosphate (ATP) and guanosine triphos-phate).
Claims that acadesine may serve as a substrate for ATP synthesis and result in repletion of myocardial ATP were supported by some studies and refuted by others. Because acadesine may be a precursor in the synthesis of myocardial ATP it was proposed as a possible agent of myocardial protection during ischaemia, particularly because myocardial ATP depletion has been linked to cell death.

Chemical Properties :Solid.

Usage:glucose uptake stimulant; AMPK activator.AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.
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www dot vit-amino dot com
ACADESINE

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