Treatment Acne Pharmaceutical Intermediates Isotretinoin

Treatment Acne Pharmaceutical Intermediates Isotretinoin / Roaccutane


Quick Details:

Product Name: Isotretinoin
Synonym: 13-cis-ra;13-cis-retinoicaci;13-ra;Isoretinoin;isotrex;neovitaminaacid;ro-4-3780
CAS: 4759-48-2
MF: C20H28O2
MW: 300.44
EINECS: 225-296-0
Assay: 99%
Appearance: Orange Crystal Powder
Specification: CP

Description:
1. As the retinoid, there are strong and fast proliferation inhibition and differentiation of skin gland cell function, effective on severe nodular cystic acne. The gastrointestinal absorption is better, while the local medication invalid. Other drugs used to treat invalid serious acne, cystic acne, acne conglobata, rosacea, ichthyosis, keratosis follicularis and pityriasis rubra pilaris and other skin diseases also have a certain effect.
2. For severe acne. Anti skin dyskeratosis medicine. For the treatment of severe acne and other disorders
3. It is also somewhat effective for hidradenitis suppurativa and some cases of severe acne rosacea. It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer.

Application:
Medical applications: The lack of nutrition of the elderly, thin, for severe burns and had the operation people.
Sports purpose: Promote muscle growth, increased training and endurance training load, it has never been proved.
Adaption: Trauma, chronic infection, malnutrition and wasting disease and All kinds of refractory anemia.

Specifications:

Items
Standards
Results
Appearance
Yellow crystals
Yellow powder
Soluble in trichloromethane, sparingly solube in ethanol,
isopropanol and polyethylene glycol, practically insoluble in water
conforms
Identification
the infrared absorbance spectrum is concordant
with the reference standard spectrum
Conforms
UV:Absorptivities at 354nm do not differ by more than 3.0%(calculated on the dried basis)
0.5%
Loss on drying
NMT0.5%
0.13%
Residue on lgnition
NMT0.1%
0.05%
Heavy Metal
NMT0.002%
<0.002%
Limit of tretinoin
NMT1.0%
0.13%
Residual solvents
Ethanol ≤5000ppm
1349ppm
Purity(HPLC)
Calculated on the dried basis
99.3%

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Treatment Acne Pharmaceutical Intermediates Isotretinoin / Roaccutane

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