Megestrol Acetate

Megestrol Acetate
English Synonyms: 17-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione;17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione;17-alpha-acetoxy-6-dehydro-6-methylprogesterone;17alpha-Acetoxy-6-dehydro-6-methylprogesterone;17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione17-acetate;5071;6-dehydro-6-methyl-17-alpha-acetoxyprogesterone;6-Dehydro-6-methyl-17alpha-acetoxyprogesterone
CAS NO.: 595-33-5
EINECS: 209-864-5
Molecular Formula:C24H32O4
Molecular Weight:384.51
Assay: 99%
Quality Standard: EP/USP
Appearance: White or light yellow crystalline powder (methanol), odorless and tasteless. Melting point 214-216. Soluble in acetone, slightly soluble in ethanol, ethyl ether, insoluble in water
Usage: Mainly used for short-acting oral contraceptives, also can be used for intramuscular injection of long-acting contraceptives. For the treatment of dysmenorrhea, amenorrhea, dysfunctional uterine bleeding, endometriosis and endometrial adenocarcinoma.
Packing:5kg/tin,20kg/drum as required

Test Items Specification Test Results
Appearance White to creamy white crystalline powder White crystalline powder
Identification IR Complies
Completeness of solution Meets the requirements.500mg being Complies
dissolved in 10ml of acetone
Solubility Insoluble in water, sparingly soluble in Complies
alcohol. Slightly soluble in ether and in
fixed oils, soluble in acetone; very soluble
in chloroform.
Melting range 213oC~220oC 217oC
Specific optical rotation +8.8°~ +12.0° +11.6°
Water ≤0.5% 0.1%
Residue roration ≤0.2% 0.06
Heavy metals ≤0.002% Complies
Assay 97.0%~103.0% 99.6%
Residual solvents Methanol≤1000ppm 74ppm
Ethanol≤1000ppm 39ppm
Methylene chloride≤500ppm 28ppm
Tetrahydrofuran≤300ppm ND
Benzene≤2ppm ND


Ethisterone CAS : 434-03-7
Norethisterone CAS:68-22-4
Ethynyl estradiol CAS:57-63-6
Ethynodiol diacetate CAS:297-76-7
Chlormadinone acetate CAS.: 302-22-7
Cyproterone acetate CAS.: 427-51-0
Megestrol acetate CAS.: 595-33-5
Estradiol CAS:50-28-2
17alpha-Oestradiol CAS: 57-91-0
Estradiol Cypionate CAS:313-06-4
Estradiol enantate CAS: 4956-37-0
Estradiol valerate CAS: 979-32-8
Estradiol Benzoatae CAS:50-50-0
Estrone CAS: 53-16-7
Estriol CAS: 50-27-1
19-Norethindrone acetate CAS:51-98-9
Norethisterone enanthate CAS:3836-23-5
Testolactone CAS:968-93-4
Eplerenone CAS: 107724-20-9
Progesterone CAS:57-83-0
Medroxyprogesterone Acetate CAS: 71-58-9

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