Product Name: Mevastatin
Synonyms: ML-236B;,8-beta(2s*,4s*),8a-beta))-;antibioticml236b;butanoicacid,2-methyl-,1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hy;compactin(penicillium);droxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha(r*),7-beta;ml236blactone;6-DEMETHYLVEVINOLIN
CAS: 73573-88-3
MF: C23H34O5
MW: 390.51
EINECS:
Product Categories: Active Pharmaceutical Ingredients;Various Metabolites and Impurities;Metabolites;Pharmaceuticals;HMG-CoA reductase;Intermediates & Fine Chemicals;Metabolites & Impurities;Cardiovascular APIs
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mp 151-153 °C
storage temp. 2-8°C
solubility DMSO: 20 mg/mL
form powder
color white
Merck 13,6186
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Chemical Properties Off-White Solid
Usage A fungal metabolite which is a potent inhibitor of HMG-CoA reductase.
Usage antihyperlipidemic, HMGCoA reductase inhibitor
Usage Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first reported in 1976. Mevastatin, the prtotype of the statin class, is a potent competitive inhibitor of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by inhibiting post-translational prenylation of proteins such as Ras, increasing
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