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Ganetespib

  • Purity: 98%
  • Price: USD 200~1500/Kilograms
  • Place of Orign: wuhan,Hubei,China
Ms.Luna Wang

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Item specifics

  • Product Name.:Ganetespib
  • CAS No: 888216-25-9

Details

Ganetespib blocked the ability of HSP90 to bind to biotinylated geldanamycin and disrupted the association of HSP90 with its cochaperone, p23, more potently than 17-AAG. In genomically defined NSCLC cell lines, ganetespib caused depletion of receptor tyrosine kinases, extinguishing of downstream signaling, inhibition of proliferation and induction of apoptosis with IC(50) values ranging 2 to 30 nmol/L, substantially lower than those required for 17-AAG (20-3,500 nmol/L). Ganetespib was also approximately 20-fold more potent in isogenic Ba/F3 pro-B cells rendered IL-3 independent by expression of EGFR and ERBB2 mutants.

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