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AT7519 hydrochloride

  • CAS No.: 902135-91-5
  • Purity: >98%
  • Weight: 418.70542
  • Formula: C16H18Cl3N5O2
  • Place of Orign: Princeton,New Jersey,United States
Ms.James Gao

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  • Product Name.:AT7519 hydrochloride
  • CAS No: 902135-91-5
  • Weight: 418.70542
  • Formula: C16H18Cl3N5O2

Details

AT7519 is a small molecule inhibitor of multi-CDK, which inhibits CDK 1, 2 , 4, 5, 6, and 9 in vitro and induces apoptosis in multiple myeloma via GSK-3 activation and RNA polymerase II inhibition. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are serine/theronine kinases involved in regulation of the cell cycle and may be overexpressed in some types of cancer cells.

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CAS No:902135-91-5 4-[(2,<br />6-dichlorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide

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