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3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]- 1-benzothiophene-2-carboxamide

  • CAS No.: 912545-86-9
  • Purity: 98%
  • Price: USD 250~1500/Kilograms
  • Weight: 490.05942
  • Place of Orign: wuhan,Hubei,China
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  • Product Name.:3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]- 1-benzothiophene-2-carboxamide
  • CAS No: 912545-86-9
  • Weight: 490.05942
  • Formula: C28H28ClN3OS

Details

SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); antagonizes Cyclopamine action at the Smo receptor. SAG potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). Induces pathway activation independently of Ptch proteins.

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CAS No:912545-86-9 3-chloro-N-[4-(methylamino)cyclohexyl]-N-[(3-pyridin-4-ylphenyl)methyl]-<br />1-benzothiophene-2-carboxamide

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