Home > Name List By 5 > 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6, 8-difluoro-4-oxoquinoline-3-carboxylic acid

CAS No 110871-86-8 , 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,
8-difluoro-4-oxoquinoline-3-carboxylic acid

  • Name: 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,
    8-difluoro-4-oxoquinoline-3-carboxylic acid
  • Synonyms: Spara; Sparfloxacine;Zagam;5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,
    8-difluoro-4-oxoquinoline-3-carboxylic acid; SPFX; Sparfloxacinum; Esparfloxacino; AT-4140; CI 978; CI-978;
  • CAS Registry Number:
  • Flash Point: 640.4°Cat760mmHg
  • Boiling Point: 640.4°Cat760mmHg
  • Density: 1.436g/cm3
  • Refractive index: 1.611
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 640.4°Cat760mmHg
  • Molecular Weight: 392.399786
  • InchiKey: DZZWHBIBMUVIIW-DTORHVGOSA-N
  • InChI: InChI=1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)
    21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,
    28)/t8-,9+
  • Risk Statements: S26;S36
  • Molecular Formula: C19H22F2N4O3
  • Molecular Structure:CAS No:110871-86-8 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,<br />8-difluoro-4-oxoquinoline-3-carboxylic acid

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References of 5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,
8-difluoro-4-oxoquinoline-3-carboxylic acid
Title: Sparfloxacin
CAS Registry Number: 110871-86-8
CAS Name: rel-5-Amino-1-cyclopropyl-7-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
Manufacturers' Codes: AT-4140; CI-978; PD-131501
Trademarks: Spara (Dainippon); Zagam (Specia)
Molecular Formula: C19H22F2N4O3
Molecular Weight: 392.40
Percent Composition: C 58.16%, H 5.65%, F 9.68%, N 14.28%, O 12.23%
Literature References: Fluorinated quinolone antibacterial. Prepn: J. Matsumoto et al., EP 221463; eidem, US 4795751 (1987, 1989 both to Dainippon). Synthesis and structure-activity relationship: T. Miyamoto et al., J. Med. Chem. 33, 1645 (1990). Antibacterial activity: S. Nakamura et al., Antimicrob. Agents Chemother. 33, 1167 (1989). Comparative in vitro antimicrobial spectrum: T. Kojima et al., ibid. 1980. Pharmacokinetics: S. Nakamura et al., ibid. 34, 89 (1990). Subacute toxicity studies: M. Yasuba et al., Chemotherapy 39, Suppl. 4, 180 (1991), C.A. 115, 247561d (1991); M. Iida et al., ibid. 195, C.A. 115, 247562e (1991).
Properties: Crystals from chloroform + ethanol, mp 266-269° (dec). pKa1 6.25, pKa2 9.30.
Melting point: mp 266-269° (dec)
pKa: pKa1 6.25, pKa2 9.30
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Synthetic); Quinolones and Analogs.