Home > Name List By d > Docetaxel

CAS No 114977-28-5 , Docetaxel

  • Name: Docetaxel
  • Synonyms: Docetaxel;Taxotere; Trihydrate; 114977-28-5; CHEBI:4672; Docetaxel; Taxotere (TN); EmDOC; Taxotere(R); Docetaxel anhydrous;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 232 ºC
  • Density: 1.37 g/cm3
  • Refractive index: 1.618
  • Alpha: -36 º (C=0.74,ETOH)
  • Safety Statements: 26-36/37
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 807.87922
  • InchiKey: ZDZOTLJHXYCWBA-VCVYQWHSSA-N
  • InChI: InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38
    (52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,
    34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,
    26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,
    32+,33-,35-,41+,42-,43+/m0/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C43H53NO14
  • Molecular Structure:CAS No:114977-28-5 Docetaxel

Related products

Search by region :

Select to

114977-28-5 Docetaxel

  • China SNC International Co., Ltd. [Distributor/Wholesaler]
  • Tel: +86-(22)-2822-1962
  • Fax: +86-(22)-2822-1960
  • Address: Room No. 711, Minmetals Building, No. 47, Xiangjiang Road, Hexi District, Tianjin 300210, null,TianjinChina
Contact Supplier

114977-28-5 Docetaxel Anhydrous

Contact Supplier

114977-28-5 Docetaxel

Contact Supplier

114977-28-5 Docetaxel

  • China Beijing Bcory Pharm-chemicals Tech.Co., Ltd. [Manufacturers]
  • Tel: +86-(10)-6087-0891
  • Fax: +86-(10)-6364-8018
  • Address: No 4,Fufeng Road, Gongshanglian Technology Building, Fengtai District, Beijing, Beijing,BeijingChina
Contact Supplier

114977-28-5 Taxotere

  • China Shanghai Sunve Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(512)-5330-1791, 5330-1685
  • Fax: +86-(512)-5330-1956
  • Address: 1 Shixi Road, Yuewang Town, Taichang, Jiangsu 215437, Shanghai,ShanghaiChina
Contact Supplier

114977-28-5 Docetaxel Anhydrous

  • China Hangzhou Heta Pharm & Chem Co., Ltd. [Manufacturers]
  • Tel: +86-(571)-88298791
  • Fax: +86-(571)-89937386
  • Address: 8# Xiyuan no.1 Road , Westlake Technologe Park, Sandun, Hangzhou 310030, Hangzhou,ZhejiangChina
Contact Supplier

114977-28-5 Taxotere

  • United Kingdom MOLEKULA Ltd. [Importer/Exporter]
  • Tel: +44 (0) 1747 83 1066
  • Fax: +44 (0) 1747 83 1199
  • Address: Brickfields Business Park Gillingham, Dorset SP8 4PX Gillingham,DorsetUnited Kingdom
Contact Supplier

114977-28-5 Taxotere

  • Canada McTony Bio&Chem [Importer/Exporter]
  • Tel: 604 249 2899
  • Address: null CANADA,CANADACanada
Contact Supplier

114977-28-5 Taxotere

Contact Supplier

114977-28-5 Taxotere

  • China Nowa pharmaceuticals Co., LTD [Manufacturers]
  • Tel: 86-512-69362785
  • Fax: 86-512-69362782
  • Address: 1355 Jinjihu Avenue (formerly 328 Jichang Road), Suzhou International Science Park, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China 215021 Suzhou,JiangsuChina
Contact Supplier

Select to

17/26
Previous 13 14 15 16 17 18 19 20 21 22 Next
References of Docetaxel
Title: Docetaxel
CAS Registry Number: 114977-28-5
CAS Name: (aR,bS)-b-[[(1,1-Dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Synonyms: N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
Manufacturers' Codes: NSC-628503; RP-56976
Trademarks: Taxotere (Aventis)
Molecular Formula: C43H53NO14
Molecular Weight: 807.88
Percent Composition: C 63.93%, H 6.61%, N 1.73%, O 27.73%
Literature References: Semisynthetic derivative of paclitaxel, q.v., prepd using a natural precursor, 10-deacetylbaccatin III, extracted from the needles of the European yew tree, Taxus baccata L., Taxaceae. Antimitotic agent that promotes the assembly of microtubules and inhibits their depolymerization to free tubulin. Prepn: M. Colin et al., EP 253738; eidem, US 4814470 (1988, 1989 both to Rh?ne-Poulenc Sante); L. Mangatal et al., Tetrahedron 45, 4177 (1989). Synthesis of the side chain: J.-N. Denis et al., J. Org. Chem. 56, 6939 (1991). Structure-activity study: F. Guéritte-Voegelein et al., J. Med. Chem. 34, 992 (1991). Cytotoxic activity and mechanism of action: I. Ringel, S. B. Horwitz, J. Natl. Cancer Inst. 83, 288 (1991). In vivo antitumor activity: M.-C. Bissery et al., Cancer Res. 51, 4845 (1991). HPLC determn: J. C. Vergniol et al., J. Chromatogr. 582, 273 (1992). Clinical pharmacokinetics and toxicology: J.-M. Extra et al., Cancer Res. 53, 1037 (1993). Clinical trials in prostate cancer: I. F. Tannock et al., N. Engl. J. Med. 351, 1502 (2004); D. P. Petrylak et al., ibid. 1513. Symposium on clinical experience: Semin. Oncol. 27, Suppl. 3, 1-29 (2000). Review of mechanism of action and combination therapies: R. S. Herbst, F. R. Khuri, Cancer Treat. Rev. 29, 407-415 (2003); of clinical studies in non-small cell lung cancer: A. M. Davies et al., Expert Opin. Pharmacother. 4, 553-565 (2003).
Properties: mp 232°. [a]D -36° (c = 0.74 in ethanol). uv max: 230, 275, 283 nm (e 14800, 1730, 1670).
Melting point: mp 232°
Optical Rotation: [a]D -36° (c = 0.74 in ethanol)
Absorption maximum: uv max: 230, 275, 283 nm (e 14800, 1730, 1670)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Taxanes.