Home > Name List By d > Docetaxel

CAS No 114977-28-5 , Docetaxel

  • Name: Docetaxel
  • Synonyms: Docetaxel;Taxotere; Trihydrate; 114977-28-5; CHEBI:4672; Docetaxel; Taxotere (TN); EmDOC; Taxotere(R); Docetaxel anhydrous;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 232 ºC
  • Density: 1.37 g/cm3
  • Refractive index: 1.618
  • Alpha: -36 º (C=0.74,ETOH)
  • Safety Statements: 26-36/37
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 807.87922
  • InchiKey: ZDZOTLJHXYCWBA-VCVYQWHSSA-N
  • InChI: InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38
    (52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,
    34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,
    26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,
    32+,33-,35-,41+,42-,43+/m0/s1
  • Risk Statements: 36/37/38
  • Molecular Formula: C43H53NO14
  • Molecular Structure:CAS No:114977-28-5 Docetaxel

Related products

Search by region :

Select to

114977-28-5 Docetaxel

  • Docetaxel
  • China Hangzhou Hysen Pharma Co.,Ltd. [Manufacturer]
  • Tel: 86-571-88298791
  • Fax: 86-571-28918299
  • Address: No.391, Wen'er Road, Hangzhou, Zhejiang, China 310012310012 hangzhouCHINA hangzhou,nullChina
Contact Supplier

114977-28-5 Taxotere

Contact Supplier

114977-28-5 Taxotere

  • China SHANGHAI BIOSUNDRUG CO.,LTD. [Manufacturers]
  • Tel: 86-21-34622765，13818080252
  • Fax: 86-21-34622765
  • Address: No. 500 Caobao Road Shanghai P.R China null,ShanghaiChina
Contact Supplier

114977-28-5 Taxotere

  • China Xianju Belter Co., Ltd [Manufacturers]
  • Tel: +86-576-87785883
  • Fax: 0086-576-8779852
  • Address: Add.: Unit 2, No 4, Siyuanhong Alley, Chengguan Town, Xianju City, 317300, Zhejiang Province, China Taizhou,ZhejiangChina
Contact Supplier

114977-28-5 Taxotere

  • China Hangzhou Haichem Co.,Ltd. [Manufacturers]
  • Tel: +86-571-86025531 / 86024803
  • Fax: +86-571-86026912
  • Address: 1218-24 Guangyin Mansion,42 Fengqi East Road Hangzhou,ZhejiangChina
Contact Supplier

114977-28-5 Taxotere

  • China Shanghai JUNJIE Bio-Technolgy [Manufacturers]
  • Tel: 86 21 - 51320300 51320301
  • Fax: 86 21 - 51320300 51320301-8018
  • Address: No. 2-502, 720 Cailun Road, Zhangjiang Hi-Tech Park,Shanghai 201203, P. R. China Shanghai,ShanghaiChina
Contact Supplier

114977-28-5 Docetaxel

Contact Supplier

114977-28-5 Docetaxel

Contact Supplier

114977-28-5 Taxotere

  • China Bettle Science and Technology Co., Ltd [Manufacturer, Trading Company]
  • Tel: 86-22-27210630
  • Fax: 86-22-27303038
  • Address: 15th floor Lawyer Building,Nanmenwai Street,Nankai District,Tianjin City null,nullChina
Contact Supplier

114977-28-5 Docetaxel Anhydrous

  • China Knowshine (Shanghai) Pharmachemicals Inc. [Manufacturers]
  • Tel: +86-(21)-51320697
  • Fax: +86-(21)-51320699
  • Address: 1043 Halei Road, Suite 306, Zhangjiang Hi-tech Park, Shanghai 201203, Shanghai,ShanghaiChina
Contact Supplier

Select to

20/26
Previous 16 17 18 19 20 21 22 23 24 25 Next
References of Docetaxel
Title: Docetaxel
CAS Registry Number: 114977-28-5
CAS Name: (aR,bS)-b-[[(1,1-Dimethylethoxy)carbonyl]amino]-a-hydroxybenzenepropanoic acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
Synonyms: N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol
Manufacturers' Codes: NSC-628503; RP-56976
Trademarks: Taxotere (Aventis)
Molecular Formula: C43H53NO14
Molecular Weight: 807.88
Percent Composition: C 63.93%, H 6.61%, N 1.73%, O 27.73%
Literature References: Semisynthetic derivative of paclitaxel, q.v., prepd using a natural precursor, 10-deacetylbaccatin III, extracted from the needles of the European yew tree, Taxus baccata L., Taxaceae. Antimitotic agent that promotes the assembly of microtubules and inhibits their depolymerization to free tubulin. Prepn: M. Colin et al., EP 253738; eidem, US 4814470 (1988, 1989 both to Rh?ne-Poulenc Sante); L. Mangatal et al., Tetrahedron 45, 4177 (1989). Synthesis of the side chain: J.-N. Denis et al., J. Org. Chem. 56, 6939 (1991). Structure-activity study: F. Guéritte-Voegelein et al., J. Med. Chem. 34, 992 (1991). Cytotoxic activity and mechanism of action: I. Ringel, S. B. Horwitz, J. Natl. Cancer Inst. 83, 288 (1991). In vivo antitumor activity: M.-C. Bissery et al., Cancer Res. 51, 4845 (1991). HPLC determn: J. C. Vergniol et al., J. Chromatogr. 582, 273 (1992). Clinical pharmacokinetics and toxicology: J.-M. Extra et al., Cancer Res. 53, 1037 (1993). Clinical trials in prostate cancer: I. F. Tannock et al., N. Engl. J. Med. 351, 1502 (2004); D. P. Petrylak et al., ibid. 1513. Symposium on clinical experience: Semin. Oncol. 27, Suppl. 3, 1-29 (2000). Review of mechanism of action and combination therapies: R. S. Herbst, F. R. Khuri, Cancer Treat. Rev. 29, 407-415 (2003); of clinical studies in non-small cell lung cancer: A. M. Davies et al., Expert Opin. Pharmacother. 4, 553-565 (2003).
Properties: mp 232°. [a]D -36° (c = 0.74 in ethanol). uv max: 230, 275, 283 nm (e 14800, 1730, 1670).
Melting point: mp 232°
Optical Rotation: [a]D -36° (c = 0.74 in ethanol)
Absorption maximum: uv max: 230, 275, 283 nm (e 14800, 1730, 1670)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Taxanes.