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CAS No 122647-31-8 , N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide

  • Name: N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide
  • Synonyms: Ibutilidum; Ibutilida [INN-Spanish]; Ibutilida; Ibutilide [INN:BAN]; IBUTILIDE FUMARATE; Corvert;Ibutilidum [INN-Latin];N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide;
  • CAS Registry Number:
  • Flash Point: 269.7°C
  • Boiling Point: 522.4°Cat760mmHg
  • Density: 1.099g/cm3
  • Flash Point: 269.7°C
  • Molecular Weight: 384.57644
  • InchiKey: ALOBUEHUHMBRLE-UHFFFAOYSA-N
  • InChI: InChI=1S/C20H36N2O3S/c1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19
    (15-13-18)21-26(3,24)25/h12-15,20-21,23H,4-11,16-17H2,1-3H3
  • Molecular Formula: C20H36N2O3S
  • Molecular Structure:CAS No:122647-31-8 N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide
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122647-31-8 Ibutilide

  • Ibutilide
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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122647-31-8 Ibutilide

  • Ibutilide, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,China
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122647-31-8 IBUTILIDE

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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122647-31-8 Methanesulfonamide,N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-

  • China Anhui BBCA Pharmaceutical Co.,Ltd [Manufacturers]
  • Tel: 86-551-4846007
  • Fax: +86-551-4846082
  • Address: No.16 weisi road,baohe industrial park,hefei,China.230051 Hefei,AnhuiChina
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122647-31-8 Methanesulfonamide,N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-

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122647-31-8 IBUTYLIDE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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References of N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide
Title: Ibutilide
CAS Registry Number: 122647-31-8
CAS Name: N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide
Molecular Formula: C20H36N2O3S
Molecular Weight: 384.58
Percent Composition: C 62.46%, H 9.44%, N 7.28%, O 12.48%, S 8.34%
Literature References: Methanesulfonanilide antiarrhythmic agent; prolongs myocardial action potential duration, predominantly by activation of slow inward sodium current. Prepn: J. B. Hester, EP 164865; idem, US 5155268 (1985, 1992 both to Upjohn); idem et al., J. Med. Chem. 34, 308 (1991). HPLC determn of enantiomers: C. L. Hsu, R. R. Walters, J. Chromatogr. B 667, 115 (1995); determn of racemate in plasma: L. Tian et al., J. Chromatogr. B 816, 81 (2005). Review of electrophysiology and pharmacology: G. V. Naccarelli et al., Am. J. Cardiol. 78, Suppl. 8A, 12-16 (1996); of pharmacology and clinical potential: R. H. Foster et al., Drugs 54, 312-330 (1997). Clinical trial in atrial flutter or fibrillation: B. S. Stambler et al., Circulation 94, 1613 (1996); J. T. VanderLugt et al., ibid. 100, 369 (1999); in elderly patients: R. M. Gowda et al., Am. J. Ther. 11, 95 (2004).
 
Derivative Type: Fumarate
CAS Registry Number: 122647-32-9
Manufacturers' Codes: U-70226E
Trademarks: Corvert (Pfizer)
Molecular Formula: (C20H36N2O3S)2.C4H4O4
Molecular Weight: 885.23
Percent Composition: C 59.70%, H 8.65%, N 6.33%, O 18.07%, S 7.24%
Properties: Crystals from acetone, mp 117-119°. uv max (95% ethanol): 228, 267 nm (e 16670, 894) Soly (mg/ml): aqueous >100 (pH £ 7).
Melting point: mp 117-119°
Absorption maximum: uv max (95% ethanol): 228, 267 nm (e 16670, 894)
 
Therap-Cat: Antiarrhythmic (class III).
Keywords: Antiarrhythmic.