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CAS No 3930-20-9 , N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide

  • Name: N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide
  • Synonyms: Sotalolum; Sotalol [INN:BAN]; Sotalolum [INN-Latin];beta-Cardone;N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide; Sorine; 3930-20-9; Sotalol Monohydrochloride; .beta.-Cardone;
  • CAS Registry Number:
  • Density: 1.239 g/cm3
  • Refractive index: 1.57
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • Molecular Weight: 272.3638
  • InchiKey: ZBMZVLHSJCTVON-UHFFFAOYSA-N
  • InChI: InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,
    16)17/h4-7,9,12-15H,8H2,1-3H3
  • Risk Statements: S26;S36
  • Molecular Formula: C12H20N2O3S
  • Molecular Structure:CAS No:3930-20-9 N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide
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3930-20-9 BETACOTDONE,99+%

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong ,Hong kong
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3930-20-9 sotalol

  • IUPAC NAME-(RS)-N-{4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl}methanesulfonamide MOLECULAR FORMULA-C12H20N2O3S MOLAR MASS-272.3624 g/mol Sotalol is a drug used in individuals with rhythm disturbances (cardiac arrhythmias) of the heart, and to trea...
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 91-240-6641875
  • Fax: 91-240-6641870
  • Address: Plot No: 04, Mayur Park Road, Harsool Aurangabad,MaharashtraIndia

3930-20-9 SOTALOL

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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3930-20-9 SOTALOL

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
  • Tel: +86-571-81956191/ +86-571-81956192
  • Fax: +86-571-81956190
  • Address: 425 MOGAN HILL ROAD ,
    HANGZHOU, 310011 CHINA ,China
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3930-20-9 SOTALOL

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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3930-20-9 Sotalol

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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3930-20-9 Sotalol

  • United States CBSCHEM LIMITED []
  • Fax: (888) 557-9843
  • Address: 621 South 48th Street, Suite 115,Tempe, AZ 85281 ,United States
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3930-20-9 sotalol

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3930-20-9 SOTALOL HCI

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
  • Fax: 514-496-4253
  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
    Canada
    H4P 2R2 ,Canada
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3930-20-9 Sotalol

  • United States Tecoland Corporation []
  • Tel: +1-(732)-603-9577
  • Fax: +1-(732)-906-1522
  • Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428, ,United States
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References of N-[4-[1-hydroxy-2-(propan-2-ylamino)ethyl]phenyl]methanesulfonamide
Title: Sotalol
CAS Registry Number: 3930-20-9
CAS Name: N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide
Synonyms: 4¢-[1-hydroxy-2-(isopropylamino)ethyl]methanesulfonanilide
Molecular Formula: C12H20N2O3S
Molecular Weight: 272.36
Percent Composition: C 52.92%, H 7.40%, N 10.29%, O 17.62%, S 11.77%
Literature References: b-Adrenergic blocker. Prepn: Uloth et al., J. Med. Chem. 9, 88 (1966). Pharmacology and toxicology: Larsen, Lish, Nature 203, 1283 (1964); Lish et al., J. Pharmacol. Exp. Ther. 149, 161 (1965); Stanton et al., ibid. 175; Kvam et al., ibid. 183. Activity of the d- and l-forms: Somani, Watson, ibid. 164, 317 (1968); Somani, Bachand, Eur. J. Pharmacol. 7, 239 (1969). HPLC determn in body fluids: W. P. Gluth et al., Arzneim.-Forsch. 38, 408 (1988). Review of pharmacology and therapeutic use: B. N. Singh et al., Drugs 34, 311-349 (1987); S. H. Hohnloser, R. L. Woosley, N. Engl. J. Med. 331, 31-38 (1994). Comprehensive description: R. T. Foster, R. A. Carr, Anal. Profiles Drug Subs. Excip. 21, 501-533 (1992).
Properties: Crystals. uv max (chloroform): 242.2, 275.2 nm. pK1 8.2, pK2 9.8.
pKa: pK1 8.2, pK2 9.8
Absorption maximum: uv max (chloroform): 242.2, 275.2 nm
 
Derivative Type: Hydrochloride
CAS Registry Number: 959-24-0
Manufacturers' Codes: MJ-1999
Trademarks: Beta-Cardone (Evans); Betapace (Berlex); Darob (Knoll); Sotacor (BMS); Sotalex (BMS)
Molecular Formula: C12H20N2O3S.HCl
Molecular Weight: 308.82
Percent Composition: C 46.67%, H 6.85%, N 9.07%, O 15.54%, S 10.38%, Cl 11.48%
Properties: White crystalline solid, mp 206.5-207° (dec), also reported as mp 218-219° (Singh). Freely sol in water; slightly sol in chloroform. Partition coefficient (water/n-octanol): 0.24; (octan-1-ol/pH 7.4 phosphate buffer) at 37°: 0.09. LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish).
Melting point: mp 206.5-207° (dec); mp 218-219° (Singh)
Log P: Partition coefficient (water/n-octanol): 0.24; (octan-1-ol/pH 7.4 phosphate buffer) at 37°: 0.09
Toxicity data: LD50 in male mice, rats (mg/kg): 2600, 3450 orally; 670, 680 i.p.; LD50 orally in rabbits: 1000 mg/kg; LD50 i.p. in dogs: 330 mg/kg (Lish)
 
Therap-Cat: Antianginal; antiarrhythmic (class II + III); antihypertensive.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Arylethanolamine Derivatives.