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CAS No 129-03-3 , 4-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine

  • Name: 4-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine
  • Synonyms: 4-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine;Eiproheptadine; Periactine; Dronactin; Periactin; Peritol; Cyproheptadiene; Periactinol; Ciproheptadina; Cypoheptadine;
  • CAS Registry Number:
  • Melting Point: 116.5 - 118
  • Flash Point: 194.5°C
  • Boiling Point: 440.1°Cat760mmHg
  • Density: 1.115g/cm3
  • Refractive index: 1.5339 (20 C)
  • Safety Statements: Poison by ingestion, intraperitoneal, subcutaneous and intravenous routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • HS Code: 29143900
  • Flash Point: 194.5°C
  • EINECS: 204-928-9
  • Molecular Weight: 287.39814
  • InchiKey: JJCFRYNCJDLXIK-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-
    3-5-9-20(17)21/h2-11H,12-15H2,1H3
  • Molecular Formula: C21H21N
  • Molecular Structure:CAS No:129-03-3 4-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine
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129-03-3 Piperidine,4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-

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129-03-3 Cyproheptadine

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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129-03-3 Piperidine,4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China ,ZheJiangChina
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129-03-3 CYPROHEPTADINE HCL

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
  • Fax: 514-496-4253
  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
    Canada
    H4P 2R2 ,Canada
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129-03-3 Cyproheptadine

  • United States CBSCHEM LIMITED []
  • Fax: (888) 557-9843
  • Address: 621 South 48th Street, Suite 115,Tempe, AZ 85281 ,United States
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129-03-3 CYPROHEPTADINE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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References of 4-(dibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-1-methylpiperidine
Title: Cyproheptadine
CAS Registry Number: 129-03-3
CAS Name: 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
Synonyms: 1-methyl-4-(5H-dibenzo[a,d]cycloheptenylidene)piperidine; 5-(1-methylpiperidylidene-4)-5H-dibenzo[a,d]cycloheptene; 1-methyl-4-(5-dibenzo[a,e]cycloheptatrienylidene)piperidine
Trademarks: Periactinol (Merck & Co.)
Molecular Formula: C21H21N
Molecular Weight: 287.40
Percent Composition: C 87.76%, H 7.36%, N 4.87%
Literature References: Prepn: Engelhardt, US 3014911 (1961 to Merck & Co.); Engelhardt et al., J. Med. Chem. 8, 829 (1965). Metabolism: C. C. Porter et al., Drug Metab. Dispos. 3, 189 (1975). Toxicity study: J. J. Loux et al., Arzneim.-Forsch. 28, 1644 (1978). Comprehensive description: H. Y. Aboul-Enein, A. A. Al-Badr, Anal. Profiles Drug Subs. 9, 155-179 (1980).
Properties: Crystals from dil ethanol, mp 112.3-113.3°.
Melting point: mp 112.3-113.3°
 
Derivative Type: Hydrochloride sesquihydrate
CAS Registry Number: 41354-29-4
Trademarks: Antegan (Frosst); Ifrasarl (Showa Shinyaku); Nuran (Frosst); Periactin (Merck & Co.); Vimicon (Frosst); Cipractin (Andromaco); Peritol (EGYT)
Molecular Formula: C21H22ClN.1?H2O
Molecular Weight: 332.87
Percent Composition: C 75.77%, H 6.96%, Cl 10.65%, N 4.21%, O 2.40%
Properties: Crystals from abs ethanol + ether, dec 252.6-253.6°. uv max (0.1N H2SO4): 224, 285 nm (E1%1cm 1656, 355). 1.0 g is sol in 1.5 ml methanol, 16 ml chloroform, 35 ml alc, 275 ml H2O. Practically insol in ether. LD50 orally in mice: 74.2 mg/kg (Loux).
Absorption maximum: uv max (0.1N H2SO4): 224, 285 nm (E1%1cm 1656, 355)
Toxicity data: LD50 orally in mice: 74.2 mg/kg (Loux)
 
Derivative Type: Hydrochloride monohydrate
CAS Registry Number: 6032-06-0
Properties: Crystals, mp 214-216°. Soly in water: ~5 mg/ml.
Melting point: mp 214-216°
 
Therap-Cat: Antihistaminic; antipruritic.
Keywords: Antihistaminic; Tricyclics; Other Tricyclics; Antipruritic.