Home > Name List By 4 > 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl] methyl]benzoic acid

CAS No 133040-01-4 , 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]
methyl]benzoic acid

  • Name: 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]
    methyl]benzoic acid
  • Synonyms: 133040-01-4;CHEBI:4814; AC1NQXXN;4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]
    methyl]benzoic acid; SKF-108566; Eprosartan (USAN/INN); SK&F-108566; CHEMBL813; SK&F 108566;
  • CAS Registry Number:
  • Flash Point: 353.3°C
  • Boiling Point: 660.6°Cat760mmHg
  • Density: 1.26g/cm3
  • Refractive index: 1.627
  • Flash Point: 353.3°C
  • Molecular Weight: 424.51266
  • InchiKey: OROAFUQRIXKEMV-LDADJPATSA-N
  • InChI: InChI=1S/C23H24N2O4S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-
    30-20)25(21)15-16-7-9-17(10-8-16)22(26)27/h4-5,7-12,14H,2-3,6,13,15H2,
    1H3,(H,26,27)(H,28,29)/b18-12+
  • Molecular Formula: C23H24N2O4S
  • Molecular Structure:CAS No:133040-01-4 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]<br />methyl]benzoic acid
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133040-01-4 EPROSARTAN

  • EPROSARTAN
  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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133040-01-4 Eprosartan

  • Eprosartan
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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133040-01-4 Eprosartan

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133040-01-4 Eprosartan

  • United States Waterstone Technology LLC [Manufacturer]
  • Tel: 317-644-0862/ 317-218-7464
  • Fax: 317-569-8068
  • Address: Waterstone Technology LLC
    12202 Hancock Street
    Carmel, IN. 46032 null,nullUnited States
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133040-01-4 EPROSARTAN

  • EPROSARTAN
  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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133040-01-4 EPROSARTAN

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133040-01-4 Eprosartan

  • Eprosartan, 99,00%
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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133040-01-4 Eprosartan

  • Eprosartan
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
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133040-01-4 Eprosartan

  • Eprosartan, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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133040-01-4 Eprosartan

  • China Watson International Ltd. null
  • Tel: +86-(512)-55117610
  • Fax: +86-(512)-55117630
  • Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332, null,nullChina
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References of 4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]
methyl]benzoic acid
Title: Eprosartan
CAS Registry Number: 133040-01-4
CAS Name: (aE)-a-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic acid
Synonyms: (E)-3-[2-butyl-1-[(4-carboxyphenyl)methyl]-imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoic acid
Manufacturers' Codes: SKF-108566
Molecular Formula: C23H24N2O4S
Molecular Weight: 424.51
Percent Composition: C 65.07%, H 5.70%, N 6.60%, O 15.08%, S 7.55%
Literature References: Prototype of the imidazoleacrylic acid angiotensin II receptor antagonists. Prepn: J. A. Finkelstein et al., EP 403159 (1990 to SmithKline Beckman); eidem, US 5185351 (1993 to SmithKline Beecham); J. Weinstock et al., J. Med. Chem. 34, 1514 (1991); R. M. Keenan et al., ibid. 36, 1880 (1993). Pharmacology: R. M. Edwards et al., J. Pharmacol. Exp. Ther. 260, 175 (1992). Receptor binding study: H. T. Schambye et al., Mol. Pharmacol. 47, 425 (1995). Clinical pharmacokinetics: D. Tenero et al., Biopharm. Drug Dispos. 19, 351 (1998). Clinical trial in hypertension: W. J. Elliott et al., J. Hum. Hypertens. 13, 413 (1999). Review of clinical experience: L. Ruilope, B. J?ger, Expert Opin. Pharmacother. 4, 107-114 (2003).
Properties: Crystals from methanol, mp 260-261°.
Melting point: mp 260-261°
 
Derivative Type: Monomethanesulfonate
CAS Registry Number: 144143-96-4
Synonyms: Eprosartan mesylate
Manufacturers' Codes: SKF-108566J
Trademarks: Teveten (Solvay)
Molecular Formula: C23H24N2O4S.CH3SO3H
Molecular Weight: 520.62
Percent Composition: C 55.37%, H 5.42%, N 5.38%, O 21.51%, S 12.32%
Properties: White to off-white crystalline powder, mp 248-250°. Insol in water. Freely sol in ethanol.
Melting point: mp 248-250°
 
Therap-Cat: Antihypertensive.
Keywords: Angiotensin II Receptor Antagonist; Antihypertensive; Imidazoleacrylic Acid Derivatives.