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CAS No 21259-20-1 , Trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3a,4b,8a)-

  • Name: Trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3a,4b,8a)-
  • Synonyms: T 2 Toxin; Insariotoxin;NSC 138780;Spiro[2,5-methano-1-benzoxepin-10,2'-oxirane], trichothec-9-ene-3,4,8,15-tetrolderiv.; 4b,15-Diacetoxy-8a-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-en-3a-ol; 8a-(3-Methylbutyryloxy)-4b,15-diacetoxyscirp-9-en-3a-ol; T 2 mycotoxin;Trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3a,4b,8a)-;Trichothec-9-ene-3a,4b,8a,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate (8CI); T 2; Fusariotoxin T 2; Mycotoxin T 2; Toxin T 2;
  • CAS Registry Number:
  • Transport: UN 3462 6.1/PG 1
  • Flash Point: 2 °C
  • Boiling Point: 544.9°C at 760 mmHg
  • Density: 1.28g/cm3
  • Refractive index: 1.546
  • Safety Statements: Poison by ingestion, intramuscular, subcutaneous, intraperitoneal, intracerebral, and intravenous routes. Moderately toxic by inhalation. Experimental teratogenic and reproductive effects. A skin irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Hazard Symbols: T+,T,Xn,F
  • Flash Point: 2 °C
  • EINECS: 244-297-7
  • Molecular Weight: 466.58
  • InChI: InChI=1/C24H34O9/c1-12(2)7-18(27)32-16-9-23(10-29-14(4)25)17(8-13(16)3)33-21-19(28)20(31-15(5)26)22(23,6)24(21)11-30-24/h8,12,16-17,19-21,28H,7,9-11H2,1-6H3/t16-,17+,19+,20+,21+,22+,23+,24-/m0/s1
  • Risk Statements: 26/27/28-38-36-20/21/22-11
  • Molecular Formula: C24H34 O9
  • Molecular Structure:CAS No:21259-20-1 Trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3a,4b,8a)-
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21259-20-1 T-2 Toxin Standard

  • Long term storage:-20℃.. Naturally occuring mycotoxin produced by many species of Aspergillus. T-2toxin is mainly found in food crops and products, and affect the blood, liver, kidney and muscle function. The clinical symptoms can be described as an...
  • China Pribolab Biotech co., Ltd. [Manufacturer, Trading Company]
  • Tel: 86-0532-68069176
  • Fax: 86-0532-68069174
  • Address: Qingdao Hechuan Rd.35 Qingdao,ShandongChina
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21259-20-1 T-2-TOXIN

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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21259-20-1 T-2 TOXIN

  • Norway Chiron AS [Manufacturer]
  • Tel: +47 73 87 44 90
  • Fax: +47 73 87 44 99
  • Address: Chiron AS
    Stiklestadveien 1
    N-7041 Trondheim
    Norway ,Norway
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21259-20-1 T2 TOXIN

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany ,Germany
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21259-20-1 2241.25-100-5AN T-2 TOXIN

  • Germany Campro Scientific GmbH [Manufacturer]
  • Tel: +49.(0)30.629.01.89.0 (Germany)/ +31.(0)318.529.437 (Netherlands)
  • Fax: +49.(0)30.629.01.89.89
    +31.(0)318.542.181
  • Address: Campro Scientific GmbH
    Postfach 36 20 65
    D-10972 Berlin
    Germany
    Tel. +49.(0)30.629.01.89.0
    Fax +49.(0)30.629.01.89.89
    info@campro.eu ,Germany
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21259-20-1 Trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3a,4b,8a)-

  • Israel Fermentek Ltd [Manufacturers]
  • Tel: 972 2 5853953
  • Fax: 972 2 5853943
  • Address: Yatziv 25, POB 47120, Jerusalem 97800 Israel Jerusalem,JerusalemIsrael
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21259-20-1 (3-ALPHA, 4-BETA, 8-ALPHA)-TRICHOTHEC-9-ENE-3,4,8,15-TETROL,12,13-EPOXY-, 4,15-DIACETATE 8-(3-METHYLBUTANOATE), MYCOTOXIN TRICHOTHECENE 2, FUSARIOTOXIN

  • Germany IRIS Biotech GmbH [Manufacturer]
  • Tel: +49 9231 9619 73
  • Fax: +49 9231 9619 99
  • Address: IRIS Biotech GmbH
    Waldershofer Str. 49-51
    D-95615 Marktredwitz, Germany ,Germany
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21259-20-1 Trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3a,4b,8a)-

  • China Beijing Rapidbio Science Co. Ltd []
  • Tel: 86-10-63395349
  • Fax: 86-10-63380700
  • Address: D0103,Wangfengjiye Building,Fengtai District, Beijing, China Beijing,BeijingChina
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21259-20-1 T-2TOXIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China ,China
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References of Trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3a,4b,8a)-
Title: T-2 Toxin
CAS Registry Number: 21259-20-1
CAS Name: (3a,4b,8a)-12,13-Epoxytrichothec-9-ene-3,4,8,15-tetrol 4,15-diacetate 8-(3-methylbutanoate)
Synonyms: 3a-hydroxy-4b,15-diacetoxy-8a-(3-methylbutyryloxy)-12,13-epoxy-D9-tricothecene; 8a-(3-methylbutyryloxy)-4b,15-diacetoxyscirp-9-en-3a-ol; fusariotoxin T-2; insariotoxin; mycotoxin T-2
Manufacturers' Codes: NSC-138780
Molecular Formula: C24H34O9
Molecular Weight: 466.52
Percent Composition: C 61.79%, H 7.35%, O 30.87%
Literature References: Tricothecene mycotoxin isolated from Fusarium tricinctum: J. R. Bamburg et al., Tetrahedron 24, 3329 (1968). Physicochemical data: A. E. Pohland et al., Pure Appl. Chem. 54, 2119 (1982). Synthesis: M. C. Wani et al., J. Org. Chem. 52, 3468 (1987). Biosynthetic study: F. Van Middlesworth et al., J. Org. Chem. 55, 1237 (1990). Toxicology studies: W. F. O. Marasas et al., Toxicol. Appl. Pharmacol. 15, 471 (1969); H. B. Schiefer, D. S. Hancock, ibid. 76, 464 (1984); D. A. Creasia et al., Fundam. Appl. Toxicol. 14, 54 (1990). Implicated as a chemical warfare agent in Southeast Asia with nivalenol, q.v.: N. Wade, Science 214, 34 (1981); R. T. Rosen, J. D. Rosen, Biomed. Mass Spectrom. 9, 443 (1982). Review: Developments in Food Science vol. 4, Y. Ueno, Ed., entitled "Trichothecenes: Chemical, Biological and Toxicological Aspects" (Kodansha Ltd. and Elsevier, New York, 1983) 310 pp. Review of pharmacokinetics and metabolism: B. Yagen, M. Bialer, Drug Metab. Rev. 25, 281-323 (1993).
Properties: Crystals, mp 151-152°. [a]D26 +15° (c = 2.58 in ethanol). Freely sol in ethyl alcohol, ethyl acetate, chloroform, DMSO and other organic solvents; slightly sol in petroleum ether; very slightly sol in water. LD50 orally in female rats: 4.0 mg/kg (Marasas). LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer).
Melting point: mp 151-152°
Optical Rotation: [a]D26 +15° (c = 2.58 in ethanol)
Toxicity data: LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer)
CAUTION: May be highly irritating to skin and mucous membranes. Direct contact may cause extensive inflammation and tissue necrosis (Marasas). Topical exposure has lead to systemic toxicity and death in experimental animals (Schiefer, Hancock).