Home > Name List By other > (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12, 16-pentamethyl-3-[(E)-1-(2-methyl-1, 3-thiazol-4-yl)prop-1-en-2-yl]-17-o...

CAS No 219989-84-1 , (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,
16-pentamethyl-3-[(E)-1-(2-methyl-1,
3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,
9-dione

  • Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,
    16-pentamethyl-3-[(E)-1-(2-methyl-1,
    3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,
    9-dione
  • Synonyms: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,
    16-pentamethyl-3-[(E)-1-(2-methyl-1,
    3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,
    9-dione;Ixempra; 219989-84-1; Ixempra (TM); Ixempra kit; CHEBI:63605; Azaepothilone B; BMS-247550; BMS 247550-1; Ixabepilone [INN];
  • CAS Registry Number:
  • Flash Point: 375.8°C
  • Boiling Point: 697.8°Cat760mmHg
  • Density: 1.122g/cm3
  • Refractive index: 1.532
  • Flash Point: 375.8°C
  • Molecular Weight: 506.69778
  • InchiKey: FABUFPQFXZVHFB-PVYNADRNSA-N
  • InChI: InChI=1S/C27H42N2O5S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-
    18(4)28-19)29-23(31)13-21(30)26(5,6)25(33)17(3)24(15)32/h11,14-15,17,
    20-22,24,30,32H,8-10,12-13H2,1-7H3,(H,29,31)/b16-11+/t15-,17+,20-,21-,
    22-,24-,27+/m0/s1
  • Molecular Formula: C27H42N2O5S
  • Molecular Structure:CAS No:219989-84-1 (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,<br />16-pentamethyl-3-[(E)-1-(2-methyl-1,<br />3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,<br />9-dione

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219989-84-1 17-Oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-,(1S,3S,7S,10R,11S,12S,16R)-

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References of (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,
16-pentamethyl-3-[(E)-1-(2-methyl-1,
3-thiazol-4-yl)prop-1-en-2-yl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,
9-dione
Title: Ixabepilone
CAS Registry Number: 219989-84-1
CAS Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
Synonyms: azaepothilone B
Manufacturers' Codes: BMS-247550; NSC-710428
Molecular Formula: C27H42N2O5S
Molecular Weight: 506.70
Percent Composition: C 64.00%, H 8.35%, N 5.53%, O 15.79%, S 6.33%
Literature References: Microtubule stabilizing semisynthetic lactam analog of epothilone B, q.v. Prepn: G. D. Vite et al., WO 9902514; eidem, US 6605599 (1999, 2003 both to Bristol-Myers Squibb); R. M. Borzilleri et al., J. Am. Chem. Soc. 122, 8890 (2000). Antineoplastic activity in vitro and in vivo: F. Y. F. Lee et al., Clin. Cancer Res. 7, 1429 (2001). Clinical evaluation with estramustine in prostate cancer: J. E. Rosenberg et al., Cancer 106, 58 (2006). Clinical pharmacokinetics and evaluation in solid tumors: S. Mani et al., Clin. Cancer Res. 10, 1289 (2004). Clinical evaluation in breast cancer: J. A. Low et al., J. Clin. Oncol. 23, 2726 (2005); in prostate cancer: M. Hussain et al., ibid. 8724. Review of pharmacology and clinical development: N. Lin et al., Curr. Opin. Invest. Drugs 4, 746-756 (2003).
Properties: Colorless oil or white lyopholizate; [a]D22 -40.7° (c = 1.0 in chloroform).
Optical Rotation: [a]D22 -40.7° (c = 1.0 in chloroform)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products.