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CAS No 220991-20-8 , 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid

  • Name: 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid
  • Synonyms: Prexige; 220991-20-8; Lumiracoxib (USAN/INN);2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid; COX189; Prexige (Novartis); COX 189; COX-189; Joicela;
  • CAS Registry Number:
  • Density: 1.363 g/cm3
  • Refractive index: 1.628
  • Molecular Weight: 293.720623
  • InchiKey: KHPKQFYUPIUARC-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12
    (15)17/h2-7,18H,8H2,1H3,(H,19,20)
  • Molecular Formula: C15H13ClFNO2
  • Molecular Structure:CAS No:220991-20-8 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid
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220991-20-8 Lumiracoxib

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
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220991-20-8 Benzeneacetic acid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-

  • China KINFON PHARMACEUTICAL AND CHEMICAL CO.LTD [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: +86-23-8650081
  • Fax: +86-23-8650081
  • Address: 7F,Commercial Building, No.3 Nanping West Road,Nan null,nullChina
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220991-20-8 Benzeneacetic acid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-

  • China VETCHEM Biochemistry Science [Manufacturer, Distributor/Wholesaler]
  • Tel: +86-21-593837
  • Address: No.2 Jinshanwei Industrial Zon,Shanghai 200120 China Shanghai,ShanghaiChina
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220991-20-8 Lumiracoxib

  • Lumiracoxib 220991-20-8 Lopinavir 192725-17-0 Masitinib 790299-79-5 Maraviroc 376348-65-1 Mecobalamin 13422-55-4 Meropenem 96036-03-2
  • China Wuhan Sunrise Technology development company limited [Manufacturers]
  • Tel: +86-27-83314682
  • Fax: 86 27 83314682
  • Address: Floor 5, Wunan Road No.15, Haixia Investment Zone, Wujiashan Wuhan, China Wuhan,HubeiChina
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220991-20-8 LUMIRACOXIB

  • China Hangzhou Hysen Pharma Co., Ltd [Manufacturer]
  • Tel: 86-571-89937383
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  • Address: Hangzhou Hysen Pharma Co., Ltd
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    HANGZHOU CHINA null,nullChina
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220991-20-8 Lumiracoxib

  • Lumiracoxib, >= 95%
  • Switzerland SynphaBase AG [Manufacturer]
  • Tel: +41 61 827 79 00
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  • Address: SynphaBase AG
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220991-20-8 Benzeneacetic acid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-

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220991-20-8 Benzeneacetic acid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-

  • China Shanghai Longsheng chemical Co.,Ltd [Manufacturers]
  • Tel: 86-21-35325969
  • Fax: 86-21-33191781
  • Address: No.3,Yuanjiang Road,Minhang District Shanghai,China Shanghai,ShanghaiChina
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References of 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid
Title: Lumiracoxib
CAS Registry Number: 220991-20-8
CAS Name: 2-[(2-Chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic acid
Synonyms: 5-methyl-2-(2¢-chloro-6¢-fluoroanilino)phenylacetic acid
Manufacturers' Codes: COX-189
Trademarks: Prexige (Novartis)
Molecular Formula: C15H13ClFNO2
Molecular Weight: 293.72
Percent Composition: C 61.34%, H 4.46%, Cl 12.07%, F 6.47%, N 4.77%, O 10.89%
Literature References: Selective cyclooxygenase-2 (COX-2) inhibitor. Prepn: R. A. Fujimoto et al., WO 9911605; eidem, US 6310099 (1999, 2001 both to Novartis). Clinical evaluation of gastroduodenal tolerability: C. Rordorf et al., Aliment. Pharmacol. Ther. 18, 533 (2003). Clinical experience in dysmenorrhea: M. Bitner et al., Int. J. Clin. Pract. 58, 340 (2004); in rheumatoid arthritis: P. Geusens et al. ibid. 1033; in tension headache: E. Packman et al., Headache 45, 1163 (2005). Review of clinical pharmacology: C. M. Rordorf et al., Clin. Pharmacokinet. 44, 1247-1266 (2005); of clinical experience in osteoarthritis: F. Berenbaum et al., J. Int. Med. Res. 33, 21-41 (2005); in osteoarthritis, rheumatoid arthritis, and dental pain: T. J. Schnitzer et al., Curr. Med. Res. Opin. 21, 151-161 (2005).
Properties: mp 158-159°.
Melting point: mp 158-159°
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Cyclooxygenase-2 Selective Inhibitor.