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CAS No 220991-20-8 , 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid

  • Name: 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid
  • Synonyms: Prexige; 220991-20-8; Lumiracoxib (USAN/INN);2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid; COX189; Prexige (Novartis); COX 189; COX-189; Joicela;
  • CAS Registry Number:
  • Density: 1.363 g/cm3
  • Refractive index: 1.628
  • Molecular Weight: 293.720623
  • InchiKey: KHPKQFYUPIUARC-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H13ClFNO2/c1-9-5-6-13(10(7-9)8-14(19)20)18-15-11(16)3-2-4-12
    (15)17/h2-7,18H,8H2,1H3,(H,19,20)
  • Molecular Formula: C15H13ClFNO2
  • Molecular Structure:CAS No:220991-20-8 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid
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220991-20-8 Benzeneacetic acid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-

  • China Yueyang Huanyu Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: 86-021-51332069,13989609991
  • Fax: 0086-730-3730599
  • Address: No. 36, Tianxing Lane, North Chengxi Road , Linxiang, Hunan, China LINXIANG,HUNANChina
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220991-20-8 Benzeneacetic acid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-

  • China Xuchang Hengsheng Pharmaceutical Co., Ltd [Manufacturers]
  • Tel: 0086-374-5698888, 0086-13782362528
  • Fax: 0086-374-5122185
  • Address: Zhangpan Fine Chemical Industrial Dictrict, Xuchang, Henan Xuchang,HenanChina
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220991-20-8 Benzeneacetic acid,2-[(2-chloro-6-fluorophenyl)amino]-5-methyl-

  • China wdfpharma [Manufacturers]
  • Tel: +86 576 8829 0708
  • Fax: +86 576 8881 3346
  • Address: 402,28 Yanyu Road,Jiaojiang,Taizhou 318000,Zhejiang,China Taizhou,ZhejiangChina
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References of 2-[2-(2-chloro-6-fluoroanilino)-5-methylphenyl]acetic acid
Title: Lumiracoxib
CAS Registry Number: 220991-20-8
CAS Name: 2-[(2-Chloro-6-fluorophenyl)amino]-5-methylbenzeneacetic acid
Synonyms: 5-methyl-2-(2¢-chloro-6¢-fluoroanilino)phenylacetic acid
Manufacturers' Codes: COX-189
Trademarks: Prexige (Novartis)
Molecular Formula: C15H13ClFNO2
Molecular Weight: 293.72
Percent Composition: C 61.34%, H 4.46%, Cl 12.07%, F 6.47%, N 4.77%, O 10.89%
Literature References: Selective cyclooxygenase-2 (COX-2) inhibitor. Prepn: R. A. Fujimoto et al., WO 9911605; eidem, US 6310099 (1999, 2001 both to Novartis). Clinical evaluation of gastroduodenal tolerability: C. Rordorf et al., Aliment. Pharmacol. Ther. 18, 533 (2003). Clinical experience in dysmenorrhea: M. Bitner et al., Int. J. Clin. Pract. 58, 340 (2004); in rheumatoid arthritis: P. Geusens et al. ibid. 1033; in tension headache: E. Packman et al., Headache 45, 1163 (2005). Review of clinical pharmacology: C. M. Rordorf et al., Clin. Pharmacokinet. 44, 1247-1266 (2005); of clinical experience in osteoarthritis: F. Berenbaum et al., J. Int. Med. Res. 33, 21-41 (2005); in osteoarthritis, rheumatoid arthritis, and dental pain: T. J. Schnitzer et al., Curr. Med. Res. Opin. 21, 151-161 (2005).
Properties: mp 158-159°.
Melting point: mp 158-159°
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Cyclooxygenase-2 Selective Inhibitor.