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CAS No 24305-27-9 , Protirelin

  • Name: Protirelin
  • Synonyms: Thyrotropin releasing hormone;Protirelin; (2S)-N-[(2S)-1-[(2S)-2-Carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-2-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide;L-Pyroglutamyl-L-histidyl-L-prolinamide;
  • CAS Registry Number:
  • Density: 1.421 g/cm3
  • Refractive index: 1.615
  • Water Solubility: 10 mg/mL, in water
  • Safety Statements: S22;S24/25
  • EINECS: 246-143-4
  • Molecular Weight: 362.38
  • InChI: InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)
  • Risk Statements: S22;S24/25
  • Molecular Formula: C16H22N6O4
  • Molecular Structure:CAS No:24305-27-9 Protirelin
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24305-27-9 Thyrotropin Trh Hormone Series Thyrotropin-Releasing Hormone

  • Product Name:Thyrotropin CAS: 24305-27-9 Molecular Formula C16H22N6O4 Molecular weight 362.38367 Apperance White powder. Applications: Thyrotropin TRH,Previous work from our laboratory prompted us to study the effects of short-term, acute administrat...
  • Min. Order: 1000
  • China Jinan Jiage Biological Technology Co., Ltd [Manufacturer]
  • Tel: 86-156-50036328
  • Address: Luneng Cambridge,Tianqiao District,Jinan,Shandong Jinan,ShandongChina
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24305-27-9 Protirelin

  • Protirelin, also known as thyrotropin-releasing hormone (TRH), causes the secretion of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. TSH acts on the thyroid gland to release the thyroid hormones thyroxine (T4) and triiodothyron...
  • Min. Order: 10
  • United States Creative Peptides [Manufacturer]
  • Tel: 1-516-6698109
  • Fax: 1-631-6147828
  • Address: 45-16 Ramsey Road Shirley New York,New YorkUnited States
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24305-27-9 Protirelin

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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24305-27-9 Protirelin

  • Switzerland Senn Chemicals AG [Manufacturer]
  • Tel: +41 (0)43 422 2400
  • Fax: +41 (0)43 422 2424
  • Address: Senn Chemicals AG
    P.O. Box 267
    Guido Senn Strasse 1, CH-8157 Dielsdorf
    Switzerland ,Switzerland
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24305-27-9 Protirelin

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China ,ZheJiangChina
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24305-27-9 Protirelin

  • China GL Biochem (Shanghai) Ltd. [Distributor/Wholesaler]
  • Tel: +86-(21)-61263306
  • Fax: +86-(21)-61263300
  • Address: 519 Zi Yue Road, Shanghai, China 200241, ShangHai,ShangHaiChina
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24305-27-9 Protirelin

  • China Xilin Chemical Group Co., Ltd []
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, ,China
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24305-27-9 321209 (2S)-N-((2S)-1-((S)-2-CARBAMOYLPYRROLIDIN-1-YL)-3-(4H-IMIDAZOL-4-YL)-1-OXOPROPAN-2-YL)-5-OXOPYRROLIDINE-2-CARBOXAMIDE H-PGLU-HIS-PRO-NH2; TRH AMIDE

  • Germany chemcube UG [Manufacturer]
  • Tel: +49 (22 08) 7 75 04 06
  • Fax: +49 (22 08) 7 75 02 30 /
    +49 (32 12) 1 00 74 76
  • Address: chemcube UG
    Salierweg 1
    53859 Niederkassel
    Germany ,Germany
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24305-27-9 Protirelin

  • China GL Biochem (Shanghai) Co., Ltd. [Manufacturers]
  • Tel: +86-21-61263307
  • Fax: +86-21-61263399
  • Address: No.519,ZiYue Road,Zizhu Science Park,Minhang District,Shanghai,China Shanghai,ShanghaiChina
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24305-27-9 Protirelin

  • United States American Peptide Company, Inc. [Manufacturer]
  • Tel: 800-926-8272/ 408-733-7604
  • Fax: 888-670-0070
  • Address: Headquarters
    American Peptide Company, Inc.
    777 East Evelyn Ave
    Sunnyvale, CA 94086
    Tel: 800-926-8272; 408-733-7604
    Fax: 888-670-0070; 408-733-7603 ,United States
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References of Protirelin
Title: TRH
CAS Registry Number: 24305-27-9
CAS Name: 5-Oxo-L-prolyl-L-histidyl-L-prolinamide
Synonyms: thyrotropin-releasing factor; thyrotropin releasing hormone; TRF; protirelin; lopremone (rescinded USAN); TSH-releasing factor; pyroglutamylhistidylprolinamide; thyroliberin
Trademarks: Antepan (Henning); Stimu-TSH (HMR); Thypinone (Abbott); Thyrefact (HMR)
Molecular Formula: C16H22N6O4
Molecular Weight: 362.38
Percent Composition: C 53.03%, H 6.12%, N 23.19%, O 17.66%
Literature References: A hypothalamic neurohormone which stimulates the release and synthesis of TSH, q.v., from the anterior pituitary via the hypophyseal portal system; the first of the hypothalamic regulatory hormones to be isolated, characterized, and synthesized. Isoln from bovine hypothalami: Schreiber et al., Experientia 18, 338 (1962); Schally et al., Endocrinology 78, 726 (1966). Purification from ovine hypothalami: Guillemin et al., C.R. Seances Acad. Sci. Ser. D 262, 2278 (1966). Isoln from porcine hypothalami and properties: Schally et al., Biochem. Biophys. Res. Commun. 25, 165 (1966); Schally et al., J. Biol. Chem. 244, 4077 (1969). Structural studies: Folkers et al., Biochem. Biophys. Res. Commun. 37, 123 (1969); Burgus et al., C.R. Seances Acad. Sci. Ser. D 269, 226 (1969). Identity of isolated TRH with synthetic tripeptide: Burgus et al., ibid. 1870; Bowers et al., Endocrinology 86, 573, 1143 (1970). Solubility: Burgus et al., Experientia 23, 417 (1967). Synthesis: Flouret, J. Med. Chem. 13, 843 (1970); Chang et al., ibid. 14, 481 (1971); E. Gross et al., Angew. Chem. Int. Ed. 12, 664 (1972); P. G. Pietta et al., J. Org. Chem. 39, 44 (1974). Review of synthetic methods: Rivier, Methods Enzymol. 37, 408 (1975). TRH is also believed to induce the secretion of the pituitary lactogenic hormone, prolactin, q.v.: Tasjian et al., Biochem. Biophys. Res. Commun. 43, 516 (1971); Bowers et al., ibid. 51, 512 (1973). It has been shown to block and reverse leukotriene-induced hypotension in the unanesthetized guinea pig: W. E. Lux et al., Nature 302, 822 (1983). Clinical studies: Hershman, N. Engl. J. Med. 290, 886 (1974). Reviews of TRH and other hypothalamic releasing hormones: Schally et al., Recent Prog. Horm. Res. 24, 497 (1968); Burgus, Guillemin, Annu. Rev. Biochem. 39, 499 (1970); Polypeptide Hormones, R. F. Beers, E. G. Bassett, Eds. (Raven Press, New York, 1980) pp 165-278.
Properties: Purified TRH is partially sol in chloroform, highly sol in absolute methanol. Completely insol in pyridine. Inactivated by diazotized sulfanilic acid (Pauly reagent) and by plasma, serum, or whole blood in vitro. Resists inactivation by proteolytic enzymes.
 
Derivative Type: Tartrate
CAS Registry Number: 54974-54-8
Trademarks: Irtonin (Takeda); Xantium (Cyanamid)
Line Formula: C16H22N6O4.xC4H6O6
 
Therap-Cat: Prohormone.
Keywords: Thyrotropic Hormone.