Home > Name List By 1 > 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine

CAS No 298-57-7 , 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine

  • Name: 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine
  • Synonyms: Stugeron; Dimitronal; Mitronal; Marisan; Stutgin; Dimitron; Labyrin; Folcodal; Midronal;1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine;
  • CAS Registry Number:
  • Flash Point: 229.8°C
  • Boiling Point: 509.2°Cat760mmHg
  • Density: 1.093g/cm3
  • Refractive index: 1.649
  • Safety Statements: Poison by intravenous route. Moderately toxic by intraperitoneal route. Experimental reproductive effects. Human systemic effects by ingestion: allergic dermatitis. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: Xn
  • Flash Point: 229.8°C
  • EINECS: 206-064-8
  • Molecular Weight: 368.51392
  • InchiKey: DERZBLKQOCDDDZ-JLHYYAGUSA-N
  • InChI: InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-
    14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+
  • Risk Statements: 20/22-36/37/38-42/43
  • Molecular Formula: C26H28N2
  • Molecular Structure:CAS No:298-57-7 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine

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References of 1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine
Title: Cinnarizine
CAS Registry Number: 298-57-7
CAS Name: 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine
Synonyms: 1-cinnamyl-4-diphenylmethylpiperazine; N-benzhydryl-N￠-trans-cinnamylpiperazine; 1-trans-cinnamyl-4-diphenylmethylpiperazine; 1-cinnamyl-4-benzhydrylpiperazine; 1-diphenylmethyl-4-trans-cinnamylpiperazine; cinnipirine
Manufacturers' Codes: 516-MD
Trademarks: Aplactan (Eisai); Aplexal (Taiyo); Apotomin (Kowa); Artate (Nippon Chemiphar); Carecin (Zensei Yakuhin); Cerebolan (Tobishi); Cerepar (Mepha); Cinaperazine (Yakult); Cinazyn (Italchimici); Cinnacet (Schwarzhaupt); Cinnageron (Streuli); Corathiem (Ohta); Denapol (Nagase); Dimitron; Eglen (Tatsumi); Folcodal (Syncro); Giganten (Troponwerke); Glanil (Janssen); Hilactan (Kyoritsu); Ixertol (Rottendorf); Katoseran (Hishiyama); Labyrin; Midronal (Delalande); Mitronal (Searle); Olamin (Sigamed); Processine (Sanko); Sedatromin (Takata); Sepan (Janssen); Siptazin (Isei); Spaderizine (Kotobuki); Stugeron (Janssen); Stutgeron (Janssen); Stutgin; Toliman (Corvi)
Molecular Formula: C26H28N2
Molecular Weight: 368.51
Percent Composition: C 84.74%, H 7.66%, N 7.60%
Literature References: Calcium channel blocker with anti-allergic and anti-vasoconstricting activity. Prepn: Janssen, US 2882271 (1959, Janssen). Pharmacology: Van Nueten, Janssen, Arch. Int. Pharmacodyn. Ther. 204, 37 (1973). Metabolism: Soudijn, van Wijngaarden, Life Sci. 7, 231 (1968). Clinical study in treatment of intermittent claudication: J. H. Barber et al., Pharmatherapeutica 2, 401 (1980). Assessment of calcium antagonist effects: M. Spedding, Arch. Pharmacol. 318, 234 (1982). HPLC determn in blood and plasma: M. Puttemans et al., J. Liq. Chromatogr. 7, 2237 (1984). Comparison of clinical pharmacokinetics with other antihistamines: D. M. Paton, D. R. Webster, Clin. Pharmacol. 10, 477-497 (1985).
 
Derivative Type: Hydrochloride
Molecular Formula: C26H28N2.HCl
Molecular Weight: 404.97
Percent Composition: C 77.11%, H 7.22%, N 6.92%, Cl 8.75%
Properties: mp 192° (dec). Soly in water: 2 mg/100 ml.
Melting point: mp 192° (dec)
 
Derivative Type: Mixture with vitamin B6
Trademarks: Emesazine
 
Therap-Cat: Antihistaminic. Vasodilator (peripheral, cerebral).
Keywords: Antihistaminic; Piperazines; Calcium Channel Blocker; Piperazine Derivatives; Vasodilator (Cerebral); Vasodilator (Peripheral).