CAS No 3385-03-3 , Pregna-1,4-diene-3,20-dione,6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6a,11b,16a)- Search by region : Germany

Name: Pregna-1,4-diene-3,20-dione,6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6a,11b,16a)-
Synonyms: Synaclyn; Nasarel; Aerospan; Syntaris;Pregna-1,4-diene-3,20-dione,6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6a,11b,16a)-; Rhinalar; Bronalide; Lunis; Aerobid;Nasalide;
CAS Registry Number:3385-03-3
Flash Point: 305.7°C
Boiling Point: 581.8°Cat760mmHg
Density: 1.33g/cm³
Safety Statements: Human systemic effects by inhalation: deviated nasal septum, ulcerated nasal septum. An experimental teratogen. Experimental reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F−.
Flash Point: 305.7°C
EINECS: 222-193-2
Molecular Weight: 434.497743
InchiKey: XSFJVAJPIHIPKU-XWCQMRHXSA-N
InChI: InChI=1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,
3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,
26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
Molecular Formula: C₂₄H₃₁FO₆
Molecular Structure:

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References of Pregna-1,4-diene-3,20-dione,6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6a,11b,16a)-

Title: Flunisolide
CAS Registry Number: 3385-03-3
CAS Name: (6a,11b,16a)-6-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
Synonyms: 6a-fluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone; 6a-fluoro-11b,21-dihydroxy-16a,17-isopropylidenedioxy-D1,4-pregnadiene-3,20-dione
Manufacturers' Codes: RS-3999
Trademarks: Aerobid (Forest); Bronalide (Syntex); Lunis (Valeas); Nasalide (Syntex); Rhinalar (Syntex); Synaclyn (Syntex); Syntaris (Syntex)
Molecular Formula: C24H31FO6
Molecular Weight: 434.50
Percent Composition: C 66.34%, H 7.19%, F 4.37%, O 22.09%
Literature References: Synthetic fluorinated corticosteroid related to prednisolone, q.v. Prepn using S. roseochromogenes: GB 933867 (1963 to Am. Cyanamid), C.A. 60, 3070f (1964). Prepn using Cunninghamella blakesleeana 8688b: H. J. Ringold, G. Rosenkranz, US 3124571; H. J. Ringold et al., US 3126375 (both 1964 to Syntex). Metabolism: N. I. Chu et al., Drug Metab. Dispos. 7, 81 (1979). Use in rhinitis: J. N. Sahay et al., Clin. Allergy 9, 17 (1979); J. K. Sarsfield, G. E. Thomson, Br. Med. J. 2, 95 (1979). Use in bronchial asthma: D. R. Webb et al., Ann. Allergy 42, 80 (1979). Clinical study in chronic asthma: R. G. Slavin et al., J. Allergy Clin. Immunol. 66, 379 (1980). Review of pharmacology and therapeutic efficacy: G. E. Pakes et al., Drugs 19, 397-411 (1980); of clinical studies with HFA formulation: S. Shafazand, G. Colice, Expert Opin. Pharmacother. 5, 1163-1173 (2004).

Derivative Type: 21-Acetate
CAS Registry Number: 4533-89-5
Manufacturers' Codes: RS-1320
Molecular Formula: C26H33FO7
Molecular Weight: 476.53
Percent Composition: C 65.53%, H 6.98%, F 3.99%, O 23.50%

Therap-Cat: Glucocorticoid; antiasthmatic.
Keywords: Antiallergic (Steroidal, Nasal); Antiasthmatic (Steroidal, Inhalant); Glucocorticoid.