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CAS No 34915-68-9 , 2-[3-(tert-butylamino)-2-hydroxypropoxy]benzonitrile

  • Name: 2-[3-(tert-butylamino)-2-hydroxypropoxy]benzonitrile
  • Synonyms: BRN 2374567; 34915-68-9; KO-1366;Bunitrolol [INN]; 2-Nitrilo-N-tert-butylphenoxypropanolamine;2-[3-(tert-butylamino)-2-hydroxypropoxy]benzonitrile; Bunitrololum [INN-Latin]; Stresson;
  • CAS Registry Number:
  • Flash Point: 204.3°C
  • Boiling Point: 414.2°Cat760mmHg
  • Density: 1.09g/cm3
  • Flash Point: 204.3°C
  • Molecular Weight: 248.3208
  • InchiKey: VCVQSRCYSKKPBA-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H20N2O2/c1-14(2,
    3)16-9-12(17)10-18-13-7-5-4-6-11(13)8-15/h4-7,12,16-17H,9-10H2,1-3H3
  • Molecular Formula: C14H20N2O2
  • Molecular Structure:CAS No:34915-68-9 2-[3-(tert-butylamino)-2-hydroxypropoxy]benzonitrile
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34915-68-9 Bunitrolol

  • Bunitrolol, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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34915-68-9 Bunitrolol

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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34915-68-9 Bunitrolol

  • Bunitrolol, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
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34915-68-9 Bunitrolol

  • Bunitrolol
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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34915-68-9 BUNITROLOL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of 2-[3-(tert-butylamino)-2-hydroxypropoxy]benzonitrile
Title: Bunitrolol
CAS Registry Number: 34915-68-9
CAS Name: 2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]benzonitrile
Synonyms: o-[3-(tert-butylamino)-2-hydroxypropoxy]benzonitrile; 1-(2-cyanophenoxy)-2-hydroxy-3-tert-butylaminopropane
Manufacturers' Codes: Ko-1366
Molecular Formula: C14H20N2O2
Molecular Weight: 248.32
Percent Composition: C 67.71%, H 8.12%, N 11.28%, O 12.89%
Literature References: b-Adrenergic blocker. Prepn: H. Koeppe et al., ZA 6803783; eidem, US 3541130 (1968, 1970 both to Boehringer, Ing.). Pharmacology: T. Kimura, Experientia 28, 813 (1972). Studies on absorption, distribution, metabolism, excretion in rats and mice: T. Suzuki, T. Rikihisa, Arzneim.-Forsch. 29, 1707 (1979). Clinical studies: A. Reale et al., J. Int. Med. Res. 4, 338 (1976); J. J. C. Jonker et al., Arzneim.-Forsch. 31, 1140 (1981). Toxicology study: M. Kanda et al., Oyo Yakuri 9, 457, 465, 499 (1975), C.A. 83, 172616 (1975).
 
Derivative Type: Hydrochloride
CAS Registry Number: 23093-74-5
Trademarks: Betriol (Boehringer, Ing.); Stresson (Boehringer, Ing.)
Molecular Formula: C14H20N2O2.HCl
Molecular Weight: 284.78
Percent Composition: C 59.05%, H 7.43%, N 9.84%, O 11.24%, Cl 12.45%
Properties: Crystals from ethanol, mp 163-165°. LD50 in mice, rats (mg/kg): 1344-1440, 639-649 orally; 264-265, 222-225 i.p. (Kanda).
Melting point: mp 163-165°
Toxicity data: LD50 in mice, rats (mg/kg): 1344-1440, 639-649 orally; 264-265, 222-225 i.p. (Kanda)
 
Therap-Cat: Antihypertensive, antiarrhythmic, antianginal.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives.