Home > Name List By 5 > 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3, 4-dihydro-2H-naphthalen-1-one

CAS No 47141-42-4 , 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,
4-dihydro-2H-naphthalen-1-one

  • Name: 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,
    4-dihydro-2H-naphthalen-1-one
  • Synonyms: Levobunolol (INN); Levobunolol HCl; Levobunololum [INN-Latin]; CCRIS 4375;Betagan; Akbeta; (-)-Bunolol; Levobunololum;5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,
    4-dihydro-2H-naphthalen-1-one;
  • CAS Registry Number:
  • Transport: 25kgs
  • Water Solubility: SOLVENT
  • Hazard Symbols: UN NO.
  • Molecular Weight: 291.3853
  • InchiKey: IXHBTMCLRNMKHZ-LBPRGKRZSA-N
  • InChI: InChI=1S/C17H25NO3/c1-17(2,
    3)18-10-12(19)11-21-16-9-5-6-13-14(16)7-4-8-15(13)20/h5-6,9,12,18-19H,4,
    7-8,10-11H2,1-3H3/t12-/m0/s1
  • Molecular Formula: C17H25NO3
  • Molecular Structure:CAS No:47141-42-4 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,<br />4-dihydro-2H-naphthalen-1-one
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47141-42-4 Levobunolol

  • IUPAC NAME-(S)-5-{[3-(tert-butylamino)-2-hydroxypropyl]oxy}-3,4-dihydronaphthalen-1(2H)-one MOLECULAR FORMULA-C17H25NO3 MOLAR MASS-291.385 g/mol
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 91-240-6641875
  • Fax: 91-240-6641870
  • Address: Plot No: 04, Mayur Park Road, Harsool Aurangabad,MaharashtraIndia

47141-42-4 1(2H)-Naphthalenone,5-[(2S)-3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-

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47141-42-4 LEVOBUNOLOL

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany ,Germany
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47141-42-4 Levobunolol

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 ,United States
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47141-42-4 LEVOBUNOLOL

  • India JAI RADHE SALES []
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. ,India
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47141-42-4 Levobunolol

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
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47141-42-4 (-)-LEVOBUNOLOL, HYDROCHLORIDE

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47141-42-4 Levobunolol

  • United States CBSCHEM LIMITED []
  • Fax: (888) 557-9843
  • Address: 621 South 48th Street, Suite 115,Tempe, AZ 85281 ,United States
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47141-42-4 (-)-LEVOBUNOLOL HYDROCHLORIDE

  • China Rongkang industry Co.,Ltd [Manufacturer]
  • Tel: +86-571-8801 0713
  • Fax: +86-571-8801 0679
  • Address: Rongkang Industry Co.,Ltd
    2-3-1502 XIANGXIELI GARDEN
    NO.4 STREET XIASHA
    HANGZHOU, CHINA P.C:310018 ,China
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47141-42-4 (-)-LEVOBUNOLOL, HYDROCHLORIDE

  • United Kingdom Molekula Group [Manufacturer]
  • Tel: +44 (0) 1747 83 1066
  • Fax: +44 (0) 1747 83 1199
  • Address: Molekula UK ltd.
    Brickfields Business Park,
    Gillingham,
    Dorset - SP8 4PX
    United Kingdom
    T : +44 (0) 1747 83 1066
    F : +44 (0) 1747 83 1199
    kevinbanks@molekula.com ,United Kingdom
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References of 5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,
4-dihydro-2H-naphthalen-1-one
Title: Levobunolol
CAS Registry Number: 47141-42-4
CAS Name: 5-[(2S)-3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone
Synonyms: (-)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-1(2H)-naphthalenone; l-bunolol
Manufacturers' Codes: W-6421A
Molecular Formula: C17H25NO3
Molecular Weight: 291.39
Percent Composition: C 70.07%, H 8.65%, N 4.81%, O 16.47%
Literature References: Nonselective b-adrenoceptor antagonist. Prepn of racemate: C. F. Schwender et al., J. Med. Chem. 13, 684 (1970); J. Shavel, Jr., S. Farber, DE 1948144; eidem, US 3641152 (1970, 1972 both to Warner-Lambert). Resolution of enantiomers: J. Shavel, Jr., C. F. Schwender, DE 2046043; eidem, US 3649691 (1971, 1972 both to Warner-Lambert); R. D. Dennis et al., US 4463176 (1984 to Bristol Myers, Mead Johnson). Cardiovascular pharmacology, anti-arrhythmic activity of racemate and isomers: R. D. Robson, H. R. Kaplan, J. Pharmacol. Exp. Ther. 175, 157, 168 (1970). Adrenoceptor blocking activity: H. R. Kaplan et al., Eur. J. Pharmacol. 16, 237 (1971). Metabolism in humans: F. J. DiCarlo et al., Clin. Pharmacol. Ther. 22, 858 (1977); F.-J. Leinweber et al., Pharmacology 16, 70 (1978). Corneal permeability: R. D. Schoenwald, H.-S. Huang, J. Pharm. Sci. 72, 1266, 1272 (1983). HPLC determn in biological fluids: H. Hengy, E. U. Kolle, J. Chromatogr. 338, 444 (1985); D. D. S. Tang-Liu et al., J. Liq. Chromatogr. 9, 2237 (1986). Clinical evaluation in hypertension: E. Arce-Gomez et al., Curr. Ther. Res. 19, 386 (1976); comparison with timolol, q.v., in glaucoma and ocular hypertension: A. Cinotti et al., Am. J. Ophthalmol. 99, 11 (1985); D. Long et al., ibid. 18. Review: H. R. Kaplan, "Levobunolol" in Pharmacology of Antihypertensive Drugs, A. Scriabine, Ed. (Raven Press, New York, 1980) pp 317-323. Brief review of long-term treatment of glaucoma: G. D. Novack, Gen. Pharmacol. 17, 373-377 (1986).
Properties: LD50 in male, female rats, mice (mg/kg): 700, 800, 1530, 1220 orally; 25, 28, 78, 84 i.v.; LD50 in male, female hamsters, dogs (mg/kg): 435, 500, 100, 100 orally (Kaplan, 1980).
Toxicity data: LD50 in male, female rats, mice (mg/kg): 700, 800, 1530, 1220 orally; 25, 28, 78, 84 i.v.; LD50 in male, female hamsters, dogs (mg/kg): 435, 500, 100, 100 orally (Kaplan, 1980)
 
Derivative Type: Hydrochloride
CAS Registry Number: 27912-14-7
Manufacturers' Codes: W-7000A
Trademarks: Betagan (Allergan); Vistagan (Allergan)
Molecular Formula: C17H25NO3.HCl
Molecular Weight: 327.85
Percent Composition: C 62.28%, H 7.99%, N 4.27%, O 14.64%, Cl 10.81%
Properties: Crystals from methanol-ether, mp 209-211°. [a]24589 -19.6±0.7° (c = 2.90 in methanol). uv max (NaOH): 221, 253, 310 nm (e 24700, 9000, 2400).
Melting point: mp 209-211°
Optical Rotation: [a]24589 -19.6±0.7° (c = 2.90 in methanol)
Absorption maximum: uv max (NaOH): 221, 253, 310 nm (e 24700, 9000, 2400)
 
Therap-Cat: Antiglaucoma.
Keywords: ?Adrenergic Blocker; Antiglaucoma.