Home > Name List By s > Sulindac

CAS No 38194-50-2 , Sulindac

  • Name: Sulindac
  • Synonyms: (Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid;Sulindac;-;
  • CAS Registry Number:
  • Transport: 3249
  • Density: 1.38 g/cm3
  • Refractive index: 1.672
  • Water Solubility: Soluble in DMSO or aqueous bases.
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 253-819-2
  • Molecular Weight: 356.41
  • InChI: InChI=1/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
  • Risk Statements: R22
  • Molecular Formula: C20H17FO3S
  • Molecular Structure:CAS No:38194-50-2 Sulindac
Search by region :

Select to

38194-50-2 Sulindac

  • Sulindac Synonyms:SULINOL;SULINDAC;SULREUMA;MK-231;Aclin;arthrocine CAS:38194-50-2 Appearance:light yellow Crystalline powder. Purity:99% MF:C20H17FO3S MW:356.41 mp :182-185°C Brief introduction: Ibuprofen analgesic effect is 10 times than Ibuprofen,...
  • Min. Order: 10
  • FOB Price: USD1 - 1 /
  • China Raw Steroid Main Shop [Manufacturer]
  • Tel: 86-0731-22290207
  • Fax: --
  • Address: Hunan zhuzhou,HunanChina
Contact Supplier

38194-50-2 SULINDAC

  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
Contact Supplier

38194-50-2 sulindac

  • China Watson International Ltd. null
  • Tel: +86-(512)-55117610
  • Fax: +86-(512)-55117630
  • Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332, null,nullChina
Contact Supplier

38194-50-2 sulindac

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
  • Fax: +86-351-7436719
  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
Contact Supplier

38194-50-2 sulindac

  • China XinChem Corporation [Manufacturers]
  • Tel: +86-(21)-34123252
  • Fax: +86-(21)-54153973
  • Address: 102/30, 3455 Chunshen Road, Shanghai 201100, null,ShanghaiChina
Contact Supplier

38194-50-2 Sulindac

  • China Simag Chemicals [Manufacturer]
  • Tel: +86 592 2680277
  • Fax: +86 592 2680237
  • Address: Simag Chemicals
    A-9D Atlantic sea view city,
    No.9 Hubin West Rd.,
    Xiamen China. null,nullChina
Contact Supplier

38194-50-2 Sulindac

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
Contact Supplier

38194-50-2 sulindac

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China null,ZheJiangChina
Contact Supplier

38194-50-2 SULINDAC

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
  • Tel: ++49 (0)2 21 9 49 83 20
  • Fax: ++49 (0)2 21 9 49 83 25
  • Address: BIOTREND Chemikalien GmbH
    Eupener Str. 157
    D - 50933 Cologne
    Germany null,nullGermany
Contact Supplier

38194-50-2 Sulindac

Contact Supplier

Select to

References of Sulindac
Title: Sulindac
CAS Registry Number: 38194-50-2
CAS Name: (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
Synonyms: cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
Manufacturers' Codes: MK-231
Trademarks: Aflodac (Janus); Algocetil (Francia); Arthrocine (Merck & Co.); Artribid (Merck & Co.); Citireuma (CT); Clinoril (Merck & Co.); Clisundac (Lagap); Reumofil (Ausonia); Reumyl (Lenza); Sudac (Errekappa); Sulinol (ICT); Sulreuma (Von Boch)
Molecular Formula: C20H17FO3S
Molecular Weight: 356.41
Percent Composition: C 67.40%, H 4.81%, F 5.33%, O 13.47%, S 9.00%
Literature References: Non-steroidal anti-inflammatory drug. Prepn: T.-Y. Shen et al., DE 2039426; eidem, US 3654349 (1971, 1972 both to Merck & Co.). Stereospecific synthesis: R. F. Shuman et al., J. Org. Chem. 42, 1914 (1977); enantioselective synthesis: A. R. Maguire et al., Synlett 2001, 41. 13C-NMR study: A. W. Douglas, Can. J. Chem. 56, 2129 (1978). Metabolism and disposition: H. B. Hucker et al., Drug Metab. Dispos. 1, 721 (1973). HPLC determn in biological fluids: D. G. Musson et al., J. Pharm. Sci. 73, 1270 (1984). Book: Current Concepts on Anti-inflammatory Drugs, K. Miehlke, Ed. (Biomedical Information Corp., New York, 1980) 240 pp. Review of pharmacology and efficacy in rheumatic disease: R. N. Brogden et al., Drugs 16, 97-114 (1978); in treatment of colorectal polyps: F. Tonelli et al., Dig. Dis. 12, 259-264 (1994). Review of clinical pharmacokinetics: N. M. Davies, M. S. Watson, Clin. Pharmacokinet. 32, 437-459 (1997).
Properties: Yellow odorless crystals from ethyl acetate, mp 182-185° (dec). uv max (methanolic 0.1N HCl): 327, 285, 256, 226 nm (E1%1cm 375, 420, 410, 540). pKa (25°) 4.7. Sparingly sol in methanol, U.S.P. alcohol; slightly sol in ethyl acetate. Practically insol in water at pH <4.5. Soly increases with rising pH to ~3.0 mg/ml at pH 7. Stable in aq acid and base. Solid stable for at least three days in air at 100°.
Melting point: mp 182-185° (dec)
pKa: pKa (25°) 4.7
Absorption maximum: uv max (methanolic 0.1N HCl): 327, 285, 256, 226 nm (E1%1cm 375, 420, 410, 540)
Therap-Cat: Anti-inflammatory.
Keywords: Anti-inflammatory (Nonsteroidal); Arylacetic Acid Derivatives.