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CAS No 29122-68-7 , 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide

  • Name: 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
  • Synonyms: Normiten; Selobloc; Tenormine; Prenormine;2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide;Tenormin; Blokium; Tenoblock; Cuxanorm; Atehexal;
  • CAS Registry Number:
  • Melting Point: 152 C
  • Boiling Point:
  • Density: 1.125 g/cm3
  • Water Solubility: Insoluble
  • Safety Statements: Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects: calcium level changes, dermatitis, leukopenia, respiratory obstruction. An experimental teratogen. Human and experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
  • Hazard Symbols: UN NO.
  • EINECS: 249-451-7
  • Molecular Weight: 266.33608
  • InchiKey: METKIMKYRPQLGS-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/
    h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)
  • Risk Statements: 22-36/37/38-20/21/22
  • Molecular Formula: C14H22N2O3
  • Molecular Structure:CAS No:29122-68-7 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
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29122-68-7 ATENOLOL

  • CAS: 29122-68-7 60966-51-0 EINECS:249-451-7 Assay:98% M.F:C14H22N2O3 M.W: 266.34 MP:154℃ BP: 508℃ at 760 mmHg Appearance:White powder Application:Pharmaceutical Raw Material Package:25kg/ paperboard barrel Standard:national standard
  • China Hubei Yuancheng Gongchuang Technology Co.,Ltd [Manufacturer]
  • Tel: 86-027-50756226
  • Address: No.496,Zhongshan Road, Wuhan, Hubei, China wuhan,HubeiChina
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29122-68-7 ATENOLOL

  • Synonym:ATENOLOL,98% 2-[4-(2-HYDROXY-3-ISOPROPYLAMINOPROPOXY)PHENYL]ACETAMIDE 2-(4-{[(2S)-2-HYDROXY-3-(PROPAN-2-YLAMINO)PROPYL]OXY}PHENYL)ACETAMIDE (2R)-3-[4-(2-AMINO-2-OXOETHYL)PHENOXY]-2-HYDROXY-N-(1-METHYLETHYL)PROPAN-1-AMINIUM (2S)-3-[4-(2-AMINO-...
  • Min. Order: 5000
  • FOB Price: USD50 - 75 /
  • China Hubei Yuancheng Saichuang Technology Co., Ltd. [Manufacturer, Trading Company]
  • Tel: 86-027-50756244
  • Fax: --
  • Address: 496# Zhongshan Road,Wuchang, Wuhan,Hubei,China wuhan ,HubeiChina
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29122-68-7 Atenolol

  • IUPAC NAME-(RS)-2-{4-[2-Hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide MOLECULAR FORMULA-C14H22N2O3 MOLAR MASS-266.336 g/mol Atenolol is used for a number of conditions including: hypertension, angina, acute myocardial infarction, supraventricu...
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 91-240-6641875
  • Fax: 91-240-6641870
  • Address: Plot No: 04, Mayur Park Road, Harsool Aurangabad,MaharashtraIndia

29122-68-7 Atenolol

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29122-68-7 Atenolol

  • Atenolol
  • Hong kong Frapp's Pharma (Hongkong) Co.,Ltd [Manufacturer]
  • Tel: +852 8130 0917
  • Fax: +852 8130 0927
  • Address: Room 801,Mongkok Harbour Centre,638 Shanghai Street,Mongkok,Kowloon,Hongkang518001 MongkokHONG KONG Mongkok,nullHong kong
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29122-68-7 Atenolol

  • Atenolol
  • China Sunkingchem Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-28-88007744
  • Fax: +86-28-85193812
  • Address: A-703, Gaofa Building, Jiuxing Road 6#, Hi-Tech Zone 610041, Chengdu, Sichuan, China.610041 ChengduCHINA Chengdu,nullChina
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29122-68-7 Atenolol

  • Atenolol, 99.0%Min
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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29122-68-7 Atenolol

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29122-68-7 Atenolol BP

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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29122-68-7 2545.14-250MG ATENOLOL

  • Germany Campro Scientific GmbH [Manufacturer]
  • Tel: +49.(0)30.629.01.89.0 (Germany)/ +31.(0)318.529.437 (Netherlands)
  • Fax: +49.(0)30.629.01.89.89
    +31.(0)318.542.181
  • Address: Campro Scientific GmbH
    Postfach 36 20 65
    D-10972 Berlin
    Germany
    Tel. +49.(0)30.629.01.89.0
    Fax +49.(0)30.629.01.89.89
    info@campro.eu null,nullGermany
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References of 2-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]acetamide
Title: Atenolol
CAS Registry Number: 29122-68-7
CAS Name: 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide
Synonyms: 2-[p-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]acetamide; 1-p-carbamoylmethylphenoxy-3-isopropylamino-2-propanol
Manufacturers' Codes: ICI-66082
Trademarks: Atehexal (Hexal); Ateno basan (Schoenenberger); Atenol (AstraZeneca); Cuxanorm (TAD); Myocord (Ivax); Prenormine (AstraZeneca); Seles Beta (Schwarz); Tenoblock (Leiras); Tenormin (AstraZeneca); Uniloc (Nycomed)
Molecular Formula: C14H22N2O3
Molecular Weight: 266.34
Percent Composition: C 63.13%, H 8.33%, N 10.52%, O 18.02%
Literature References: Cardioselective b-adrenergic blocker. Prepn: Barrett et al., DE 2007751; eidem, US 3663607 and US 3836671 (1970, 1972, 1974 all to I.C.I.). Pharmacology and clinical studies: Giudicelli et al., C.R. Seances Soc. Biol. Ses Fil. 167, 232 (1973); Hansson et al., Acta Med. Scand. 194, 549 (1973); Amery et al., N. Engl. J. Med. 290, 284 (1974). Clinical trial in treatment of alcohol withdrawal syndrome: M. L. Kraus et al., ibid. 313, 905 (1985). HPLC determn of enantiomers in plasma and urine: S. K. Chin et al., J. Chromatogr. 489, 438 (1989). Comprehensive description: V. Caplar et al., Anal. Profiles Drug Subs. 13, 1-25 (1984). Review: J. D. Fitzgerald in Pharmacological and Biochemical Properties of Drug Substances vol. 2, M. E. Goldberg, Ed. (Am. Pharm. Assoc., Washington, DC, 1979) pp 98-147; E. Marmo, Drugs Exp. Clin. Res. 6, 639-663 (1980). Symposium on clinical studies: Drugs 25, Suppl. 2, 1-346 (1983).
Properties: Crystals from ethyl acetate, mp 146-148°. Also reported as mp 150-152° (Caplar). Freely sol in methanol; sol in acetic acid, DMSO; sparingly sol in 96% ethanol; slightly sol in water, isopropanol; very slightly sol in acetone, dioxane. Practically insol in acetonitrile, ethylacetate, chloroform. pKa 9.6. Partition coefficient (n-octanol/phosphate buffer): 0.008 (pH 7.0); 0.052 (pH 8.0). Dipole moment: 5.71 ±0.20 D at 20° in propionic acid. uv max (methanol): 225, 275, 283 nm. LD50 in mice, rats (mg/kg): 2000, 3000 orally; 98.7, 59.24 i.v. (Fitzgerald).
Melting point: mp 146-148°; mp 150-152° (Caplar)
pKa: pKa 9.6
Log P: Partition coefficient (n-octanol/phosphate buffer): 0.008 (pH 7.0); 0.052 (pH 8.0)
Absorption maximum: uv max (methanol): 225, 275, 283 nm
Toxicity data: LD50 in mice, rats (mg/kg): 2000, 3000 orally; 98.7, 59.24 i.v. (Fitzgerald)
Therap-Cat: Antihypertensive, antianginal, antiarrhythmic (class II).
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives.