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CAS No 4342-03-4 , Dacarbazine

  • Name: Dacarbazine
  • Synonyms: Dacarbazine;5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide; 4-(3,3-Dimethyltriazeno)imidazole-5-carboxamide; 4-(Dimethyltriazeno)imidazole-5-carboxamide;
  • CAS Registry Number:
  • Melting Point: 199-205 ºC
  • Flash Point: 229.7 ºC
  • Boiling Point: 456.3 ºC at 760 mmHg
  • Density: 1.48 g/cm3
  • Refractive index: 1.678
  • Water Solubility: slightly soluble in ethanol and water
  • Safety Statements: R45;R46;R20/21/22;R36/37/38
  • Hazard Symbols: T: Toxic;
  • Flash Point: 229.7 ºC
  • EINECS: 224-396-1
  • Molecular Weight: 182.18
  • InChI: InChI=1/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
  • Risk Statements: S53;S36/37/39;S45
  • Molecular Formula: C6H10N6O
  • Molecular Structure:CAS No:4342-03-4 Dacarbazine

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References of Dacarbazine
Title: Dacarbazine
CAS Registry Number: 4342-03-4
CAS Name: 5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide
Synonyms: 5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide; DIC; DTIC
Manufacturers' Codes: NSC-45388
Trademarks: Dacatic (L×kefarmos); DTIC-Dome (Bayer); Deticene (Bellon)
Molecular Formula: C6H10N6O
Molecular Weight: 182.18
Percent Composition: C 39.56%, H 5.53%, N 46.13%, O 8.78%
Literature References: First synthesized in 1959 at the Southern Research Institute. Prepn: Shealy et al., J. Org. Chem. 27, 2150 (1962); Hano et al., Gann 59, 207 (1968), C.A. 69, 42527g (1968). Antitumor activity: Shealy et al., Biochem. Pharmacol. 11, 674 (1962); Hano et al., Gann 56, 417 (1965), C.A. 63, 18856g (1965). Mechanism of action studies: Saunders, Schultz, Biochem. Pharmacol. 19, 911 (1970). Metabolism: Skibba et al., ibid. 2043; Mizuno, Humphrey, Cancer Chemother. Rep. Part 1 56, 465 (1972). Review: Carter, Friedman, Eur. J. Cancer 8, 85-92 (1972), see also the series of articles on history, activity, mechanism of action and clinical studies: Cancer Treat. Rep. 60, 123-214 (1976).
Properties: Ivory microcrystalline substance; explosive decomp 250-255°. Also reported as mp 205°, Hano et al., loc. cit. (1965). uv max (0.1N HCl): 223 nm (7500); (pH 7): 237 nm (11200); both solns protected from light. Stable in neutral soln in absence of light.
Melting point: mp 205°, Hano et al., loc. cit. (1965)
Absorption maximum: uv max (0.1N HCl): 223 nm (7500); (pH 7): 237 nm (11200); both solns protected from light
CAUTION: This substance is reasonably anticipated to be a human carcinogen: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-76.
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkylating Agents.